resultados
Busca
Comunidades no DSpace
Selecione uma comunidade para navegar por suas coleções
Submissões Recentes
listelement.badge.dso-type Item , Effects of the whey proteins on the nutritional status and immunomodulation of end-stage chronic liver disease patients.(Universidade Federal de Minas Gerais, 2020-09-23) Yani Glaucia Gomide MizubutiDesnutrição e disfunção imunológica contribuem para alta mortalidade de pacientes com doença hepática crônica (DHC). Proteínas de elevado valor nutricional e que contenham componentes imunomoduladores, como as do leite de vaca, podem melhorar estas condições quando consumidas. Neste estudo, avaliaram-se as propriedades imunomoduladoras das proteínas do soro do leite (WP), em comparação à caseína (CA), pela viabilidade celular e concentrações de citocinas no sobrenadante de células mononucleares do sangue periférico (CMSP) de indivíduos saudáveis (n=5) e com DHC (n=8). Estes parâmetros foram avaliados com e sem estímulo, pós-exposição com 40, 400 ou 4.000 μg/mL de WP ou CA. Na concentração 4.000 μg/mL, WP diminuiu a morte de linfócitos em indivíduos saudáveis (WP= 5%; CA= 20%, p = 0,0159) e com DHC (WP= 6%; CA= 11%, p = 0,0104) e aumentou, mediante estímulo, as citocinas TNF (WP= 517 pg/mL; CA= 187 pg/mL, p = 0,0047) e IL-10 (WP= 27 pg/mL; CA= 9 pg/mL, p = 0,0281) em pacientes com DHC. Posteriormente, avaliou-se o efeito da suplementação com WP em pacientes com DHC sobre o estado nutricional e a imunomodulação, mantendo CA como controle; (n=95). Os pacientes também foram avaliados de acordo com MELD (model for end-stage liver disease), sendo menos (MELD <15, n=29) e mais (MELD ≥ 15, n=66) graves. Desnutrição foi observada em 57,4% e 54,2% dos pacientes nos grupos WP e CA, respectivamente (p = 0,649), pela Avaliação Global Subjetiva no início do estudo, sem diferenças quando estratificados por MELD [38,5% e 33,3% (p = 0,778) nos grupos WP e CA MELD <15 e 64,5% e 62,5% (p = 0,868) nos grupos WP e CA MELD ≥15, respectivamente]. Não houve alterações na composição corporal, funcionalidade muscular e ingestão de proteínas. Houve maior probabilidade de encefalopatia no grupo WP MELD≥15 (OR = 1,18; IC 95%: 1,04; 1,35, p = 0,008) e aumento na taxa metabólica de repouso (β = 0,29; IC 95%: 0,12; 0,46, p = 0,001) no grupo WP MELD<15, pós suplementação. Antes da suplementação, a maior concentração de IL-10 no grupo WP (média = 14,53 pg/mL; IC 95%: 11,54; 17,52 vs grupo CA, média = 10,81 pg/mL; IC 95% : 8,79; 12,82, p = 0,044) não foi mantida após a suplementação (β = 0,15; IC 95%: -0,10; 0,41, p=0,241). As quimiocinas alteraram no grupo WP pós suplementação: concentrações aumentadas de IP-10 / CXCL-10 (β = 0,43; IC 95%: 0,06; 0,81, p = 0,022), Eotaxina-1/CCL11 (β = 0,22; IC 95%: 0,02; 0,42, p = 0,031) e MCP1/CCL2 (β = 0,35; IC 95%: 0,06; 0,64, p = 0,018) e reduzidas de IL-5 (β = -0,17; IC 95%: - 0,31; -0,01, p = 0,027), inclusive no grupo WP MELD≥15 [IP-10 / CXCL-10 (β = 0,64; IC 95%: 0,23; 1,06, p = 0,002); Eotaxina-1/CCL11 (β = 0,42; IC 95%: 0,13; 0,72, p = 0,004); MCP-1/CCL2 (β = 0,68; IC 95%: 0,25; 1,12, p = 0,002) e IL-5 (β = -0,28; IC 95%: -0,52; - 0,04, p = 0,022), além do aumento na IL-10 (β = 0,38; IC 95%: 0,10; 0,66, p = 0,008). Em conclusão, WP exerceu efeito imunomodulador in vitro e in vivo, sem impacto sobre o estado nutricional, quando comparado à caseína.listelement.badge.dso-type Item , Estudos de casos: entre arquiteturas e sobrevivências(Universidade Federal de Minas Gerais, 2025-12-12) Lais MyrrhaThis doctoral dissertation begins with the need to understand art as a condenser of times and spaces, a field in which past, present, and future intertwine in critical, poetic, and political ways. In this context, the figure of the surviving artist appears as that of someone who never completes their formation and whose main activity would be to sustain and expand their own community, as well as the field of art, in parallel with institutional and market structures (or despite them). Although the works that guide this writing refer to Oscar Niemeyer’s architecture and the city of Brasília, the central axis of the project is not architecture itself, but the reflections that emerge from it and from its presence as image: the way it enters history and the imagination, and what it reveals about our ideas of the future. Beginning with the installation Dois pesos, duas medidas [Two Weights, Two Measures] (2016), presented at the 32nd São Paulo Biennial, and extending to the works in the Estudos de caso [Case Studies] series, the text and the images that supplement it propose a critical reading of the systems of values and representations that shape the modern Brazilian imagination, articulating memory, monument, and power. The notion of the future is also put under tension throughout the work. If, at the time of Brasilia’s construction, the future was proclaimed as a promise of progress and national redemption, today it is often perceived as a frustration. The work I present suggests that this sense of an “interrupted” or “frustrated” future exists only because it is anchored in a universal and linear conception of History. By contrast, the research proposes thinking about how certain works atomize this notion of the future, opening the way to the invention of multiple, dispersed, and contingent temporalities, and to the futures that emerge from them as possibilities rather than as destiny.listelement.badge.dso-type Item , A multimodalidade nas questões do ENEM: um estudo da proiciência leitora no ensino médio(Universidade Federal de Minas Gerais, 2028-12-19) Juliana de Paiva Vieira SoaresThis study presents results of a research that examined the level of reading proficiency of 3rd year high school students in multimodal texts present in the National Examination of Secondary School (Enem), from 2010 to 2015. The purpose is to verify if students master skills and abilities in reading multimodal texts, as well as propose improvement to their reading proficiency, aiming at not only positive results in external evaluations, but also to increase the reading capacity in other relevant contexts of the life of these young people. As a research context, a school of the State Public School Network of Minas Gerais was located in Ribeirão das Neves. The target audience consisted of a Portuguese Language teacher and 31 students from a 3rd grade high school class. It is a qualitative research that involved bibliographical, documentary and field research. The theoretical contribution is supported by contributions of authors who research Youth and High School, Reading Teaching and Multimodality in the issues of the Enem, such as: Correia e Linhares (2014), Coscarelli (2009, 2010, 2016), Days and (2009), Novais (2009), Dayrrel (2014), Gomes (2003, 2015, 2016), Marcuschi (2015), Paiva e Costa (2012), Ribeiro (2006; others. The results revealed that large-scale external evaluations, among them Enem, attest to students' difficulties in applying reading skills autonomously. The results also indicated demands for changes in reading teaching, as well as appropriation of the results of the Wide Scale assessments as a teaching tool in the acquisition of reading skills and competences. At the end of the research, a proposal was presented for a Didactic Sequence on multimodal texts, aimed at improving the reading proficiency of high school students.listelement.badge.dso-type Item , Frequência regular das pessoas educandas jovens da EJA: causas e motivos da permanência na escola em Vespasiano/MG(Universidade Federal de Minas Gerais, 0005-06-25) Lídia Aparecida da Silva CostaThis dissertation investigates the causes and motivations that contribute to the regular attendance of young people aged 15 to 21 enrolled in Youth and Adult Education (EJA) during the final years of elementary education, in the evening shift of a municipal public school located in Vespasiano, Minas Gerais, Brazil. This qualitative study was carried out through document analysis, a semi-structured group interview, and observation of school dynamics. Empirical data were collected from three students and the EJA program’s pedagogical coordinator. The theoretical framework is grounded in the work of Paulo Freire, Miguel Arroyo, Gaudêncio Frigotto, Analise da Silva, Letícia Carneiro Conceição, among others, whose reflections engage with issues of youth, school persistence, the right to education, and social equity. The findings indicate that student persistence is shaped by both external factors—such as institutional support, family encouragement, and connections with teachers—and internal ones, including the desire to overcome personal challenges, the value placed on schooling, and individual life goals. As a practical contribution, the study developed an educational resource titled Motivational Workshop Notebook for EJA Youth, which offers monthly pedagogical activities aimed at strengthening school attendance and student engagement. The study concludes that intentional, dialogical, and youth-responsive pedagogical practices can foster a sense of belonging and meaningfully support student persistence in EJA, reaffirming the school as a space for listening, transformation, and the guarantee of rights.listelement.badge.dso-type Item , Entre forjas e jardins(Universidade Federal de Minas Gerais, 2025-12-11) Dyana dos SantosBETWEEN FORGES AND GARDENS is a weaving that unfolds from three-dimensional works created between 2014 and the present, forming a research process both woven and forged between the practices of sewing and metallurgy; between craftsmanship and what is conventionally understood as art; between the bodily performances within the studio and digital writing; between a language that alternates between academic writing and oral storytelling, in order to propose reflections on artistic practice and the social structures that shape the artist’s existence. In a mode of writing akin to that of artist-writers, the text interlaces artworks, studio processes, everyday reflections, and textual and visual references, forming a weave—or alloy—of critical thought on colonization and the ongoing coloniality embedded in the invention of Brazil. The work will be divided into two parts. BETWEEN FORGES gathers artworks and reflections that confront and challenge the dimensions of violence imposed by colonial forges upon our bodies, arts, thoughts, and existence. GARDENS, in turn, reverses the plantation logic of cultivation, presenting itself as a practice of nurturing creativity, constructing and sustaining subjectivities, and envisioning other worlds and futurities. It arises as a rescue of my mothers’ “gardens” (in reference to the essay “In Search of Our Mothers’ Gardens”, in which Alice Walker reflects on how women without access to formal artistic means preserved their technologies and civilizational modes through gardens, sewing, and other forms of creation).