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listelement.badge.dso-type Item , Fatores associados aos distúrbios do sono em crianças e adolescentes com transtorno do espectro autista(Universidade Federal de Minas Gerais, 2025-06-13) Luana Tainá Marques AgostinhoO Transtorno do Espectro Autista (TEA) é um transtorno complexo do desenvolvimento neurológico, que acarreta problemas no convívio social, dificuldades de comunicação e prática de comportamentos repetitivos. Crianças e adolescentes com essa condição comumente apresentam outras desordens como hiperatividade, autoagressão, agressividade, inquietação, ansiedade e distúrbios do sono. O objetivo do presente estudo foi avaliar os fatores associados aos distúrbios do sono em crianças e adolescentes com TEA. Trata-se de um estudo transversal, com 50 crianças e adolescentes com TEA atendidas pela Fundação Centro Integrado de Apoio à Pessoa com Deficiência (FUNAD), situada em João Pessoa, Paraíba, Brasil. O possível bruxismo do sono (PBS) foi utilizado como critério de diagnóstico a partir do relato dos pais/responsáveis. Foi utilizada a Escala de Estresse Percebido (PSS- 10) para avaliar o estresse dos pais/responsáveis e a Escala de Distúrbios do Sono para Crianças (SDSC) para verificar a presença de distúrbios do sono na criança/adolescente. Os dados obtidos foram analisados estatisticamente no programa Statistical Package for the Social Sciences (SPSS) versão 22.0 e foram realizadas análise descritiva e regressão de Poisson univariada e multivariada (IC95%, p<0,05). Observou-se que a média do escore total da Escala de Distúrbios do Sono em Crianças (EDSC) foi de 48,84, já a prevalência do possível bruxismo do sono em crianças e adolescentes com TEA foi de 28%. O modelo final ajustado revelou associação entre a escolaridade dos pais/responsáveis equivalente ao ensino médio completo ou inferior (RP: 1,30; IC95%:1,12-1,51; p < 0,001), o uso de chupeta na infância (RP: 1,17; IC95%: 1,01-1,36; p = 0,029) e o PBS (RP: 1,30; IC95%: 1,08- 1,56; p = 0,005) com a média do escore total da EDSC. Concluiu-se que a baixa escolaridade dos pais/responsáveis e o uso de chupeta na infância e o PBS foram associados à maior ocorrência de distúrbios do sono nas crianças e adolescentes com TEA. Destaca-se que a compreensão, o diagnóstico e o manejo dos distúrbios do sono e do bruxismo em crianças e adolescentes com TEA são fundamentais para um desenvolvimento mais saudável, assim como para uma melhor qualidade de vida.listelement.badge.dso-type Item , Universo em migalhas: biografema em Roland Barthes por Roland Barthes(Universidade Federal de Minas Gerais, 2025-08-29) Thaynara Caroline Faleiro Malta RezendeThis research investigates the notion of biographeme in Roland Barthes by Roland Barthes, a work composed of images and textual fragments, articulating this concept with autofictional writing. Although subjectivity manifests in a dispersed and fragmented manner, the study argues that it is possible to recognize traces left by the author’s body—marks that resist time, forgetting, and erasure. The central hypothesis maintains that the biographeme is a remainder: an involuntary, indexical residue that escapes complete signification. To demonstrate this hypothesis, were analyzed textual fragments and photographs that compose the work. The research engages in an interdisciplinary dialogue with psychoanalysis, aesthetics, philosophy, semiotics, and memory studies, proposing a connection between the biographeme and photography, given their shared indexical nature. Finally, Roland Barthes by Roland Barthes is understood as a kaleidoscopic montage that dismantles the linearity of autobiographical narrative and reinscribes the subject through remnants—visual and textual flashes—that emerge as persistent traces, revealing the biographeme’s power of survival.listelement.badge.dso-type Item , Medo do parto: possibilidades para avaliar e intervir(Universidade Federal de Minas Gerais, 2025-08-22)Introduction: Childbirth is a physiological process that involves physical, emotional, psychological, social and cultural aspects. This experience is expected to be positive with the birth of a healthy baby in a safe environment, emotional and practical support, and a qualified healthcare team. Many pregnant women report fear related to childbirth, fear of not bonding with the baby, of how professionals will act, and of feeling alone. Fear of childbirth is defined as intense anxiety that affects well-being and daily activities. Its repercussions include an increase in spontaneous abortions, higher rates of elective cesarean sections, and epidural analgesia. Identifying pregnant women who experience this fear and understanding its causes is essential for implementing care strategies to reduce these feelings and promote self-confidence. Objective: To understand women's perceptions of their experience during labor, to investigate the influence of the Oficina do Parto (OP) on labor and childbirth and to translate and validate the Fear of Childbirth Questionnaire (FCQ) into Brazilian Portuguese. Method: A qualitative and a methodological study were conducted. The first involved pregnant women who participated in OP, and who answered a semi-structured interview during the postpartum period. The results were interpreted using content analysis principles. The methodological study involved pregnant women using public health services at the Federal University of Minas Gerais. The translation and cross-cultural adaptation of the FCQ followed the stages proposed by Beaton et al. (2000) and the COSMIN guidelines. Content validity and internal consistency reliability were assessed according to COSMIN criteria. Construct validity was evaluated through the clustering of fear types proposed by the authors of the original questionnaire. Results: Nine women participated in the qualitative study and two thematic axes were identified: 1) Pregnant women's perceptions of the OP contribution to labor and childbirth and 2) Postpartum women's experiences regarding the participation of a companion during labor and childbirth. In the methodological study, after translation and cross-cultural adaptation, 100 pregnant women completed the FCQ. Content validation of the FCQ-BR showed adequate CVI for clarity, comprehensiveness and relevance. Construct validity was moderate to low. Internal consistency was high. Conclusion: The OP facilitated communication, access to information and knowledge exchange between professionals and pregnant women. Participants reported both facilitators and barriers to applying the knowledge during childbirth, mostly related to the performance of the healthcare team. The FCQ-BR proved to be a valid and reliable tool for assessing fear of childbirth among Brazilian pregnant women.listelement.badge.dso-type Item , INTEGR@R: produção textual em aulas de informática(Universidade Federal de Minas Gerais, 0002-07-25) Rosângela Fonseca da SilvaThis paper describes a study of text production in virtual environments, providing greater discussion of the multimodal infographic genre, carried out in the computer lab of the Universidade Federal da Bahia through the project “Integr@r: towards digital fluency”, proposed by the SANKOFA program and with the general objective of appropriating virtual resources for the development and improvement of text production for students enrolled mainly in the public school system and linked to the Emília Machado Association of the Marechal Rondon community in Salvador. The work is part of an applied action research, with a qualitative approach, specifically aiming to analyze the students' reception, the data produced and the results obtained through the methodology applied based on the theoretical foundations of the studies of PAIVA (2009). This work will briefly discuss the paths and didactic strategies for working on writing in virtual environments, from the reception of the first activity with the academic genre critical review, a driving force for scientific initiation, to the pedagogical investigation of the multimodal infographic genre, the object of research and application, focusing on the analysis of student engagement and production in the elaboration of the proposed multimodal genre.listelement.badge.dso-type Item , Avaliação do potencial de padrões de miRNAs como preditores de resposta patológica em pacientes com câncer de mama submetidos à terapia neoadjuvante(Universidade Federal de Minas Gerais, 2025-08-13) Álvaro Percínio CostaNeoadjuvant therapy in breast cancer allows for the assessment of the degree of pathological response in the surgical specimen, providing prognostic and predictive information to guide subsequent treatments. Pathological complete response (PCR) is a prognostic factor widely associated with overall survival and is commonly used as a surrogate endpoint in neoadjuvant studies. Small non-coding RNAs, such as microRNAs (miRNAs), play crucial roles in various carcinogenic pathways and show promise as predictors of PCR. Developing a molecular signature of miRNAs extracted from tumor-derived extracellular vesicles (EVs) in peripheral blood holds potential for use as a biomarker. This approach could optimize neoadjuvant protocols to increase PCR rates and reduce toxicity. The present study aims to investigate the association between miRNAs derived from EVs and pathological complete response in patients with breast cancer undergoing neoadjuvant therapy. To this end, circulating EVs were isolated from peripheral blood samples collected before neoadjuvant treatment from 48 patients with breast cancer. Total RNAs contained in these vesicles were extracted using silica column-based methods and sequenced through next-generation sequencing (NGS). The miRNA expression patterns were correlated with PCR in surgical specimens through bioinformatics analysis, in order to obtain prognostic information. Among the 48 patients analyzed, a differential expression profile was noted in 12 patients with triple-negative breast cancer. Bioinformatics analysis revealed that overexpression of hsa-mir-489-5p was present in patients who achieved PCR, while overexpression of hsa-mir-1237-3p and hsa-mir-600-5p was observed in those without a complete pathological response. These findings suggest that hsa-mir-489-5p acts as a tumor suppressor, while hsa-mir-1237-3p and hsa-mir-600-5p function as oncomiRs, showing predictive potential for PCR. These miRNAs may represent a potential new tool for predicting response to neoadjuvant treatment, contributing to a more personalized and less invasive approach to breast cancer management.