Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression

Karina Braga Gomes Borges

Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/36787

Tipo:	Artigo de Periódico
Título:	Il-6 and type 1 diabetes mellitus: t cell responses and increase in il-6 receptor surface expression
Autor(es):	Karina Braga Gomes Borges
Resumo:	Type 1 diabetes mellitus (T1D) is an autoimmune disease characterized by beta cell destruction, associated with cellular infiltration and inflammatory responses in the islets of Langerhans. The cellular components of this infiltrate include monocytes, macrophages, CD4+ and CD8+ T cells, and the balance between Th1 and Th2 cells is crucial in the pathogenesis of this disease. Cytokines play important role in the development and activation of immune cells, since they act as cell-signaling molecules, especially in autoimmune diseases, including T1D. Moreover, cytokines may serve as additional biomarkers of T1D. Cytokines may also provide valuable information about the pathways involved in the regulation of T1D processes. Interleukin-6 (IL-6), a multifunctional cytokine, is secreted by T cells and macrophages to stimulate immune response during inflammation and infection. Indeed, this cytokine is involved in the inflammatory response associated with insulin-resistant states.
Assunto:	Diabetes mellitus tipo 1
Idioma:	eng
País:	Brasil
Editor:	Universidade Federal de Minas Gerais
Sigla da Instituição:	UFMG
Departamento:	FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
Tipo de Acesso:	Acesso Aberto
Identificador DOI:	10.21037/atm.2016.12.74
URI:	http://hdl.handle.net/1843/36787
Data do documento:	2017
metadata.dc.url.externa:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253293/pdf/atm-05-01-16.pdf
metadata.dc.relation.ispartof:	Annals of Translational Medicine
Aparece nas coleções:	Artigo de Periódico

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