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http://hdl.handle.net/1843/39593
Type: | Artigo de Periódico |
Title: | Neutrophil-to-lymphocyte ratio used as prognostic factor marker for dilated cardiomyopathy in childhood and adolescence |
Other Titles: | Relação neutrófilo-linfócito utilizada como marcador de fator prognóstico para cardiomiopatia dilatada na infância e adolescência |
Authors: | Fatima Derlene da Rocha Araujo Rosemary Ferreira da Lisboa Silva Camilla Andrade Lima Oliveira Zilda Maria Alves Meira |
Abstract: | Objective: The objective of this study is to evaluate the neutrophil-to-lymphocyte ratio (NLR) and platelet–lymphocyte ratio, from the hemograms obtained from children and adolescents with dilated cardiomyopathy (DCM), and to correlate them with the levels of B-type natriuretic peptide (BNP) and with the clinical evolution of these patients in the long term. Materials and Methods: Follow-up of 57 patients with DCM was made retrospectively, with hemogram and BNP level determination being performed after optimized therapy for heart failure. We compared the findings of the patients' examinations that progressed with stability in relation to the occurrence of transplant listing, cardiac transplantation, or evolution to death. Results: The average age was 48 months, and the follow-up was 64 months. The average of the levels of neutrophils was greater in poor evolution group (7026 vs. 3903; P = 0.011) as well as the average of NLR (5.5 vs. 1.9; P = 0.034). The averages of hemoglobin, total leukocytes, lymphocytes, and platelets were similar in the groups. The area under the receiver operating characteristic curve for NLR in relation to the poor evolution was of 72.9%, being the best cutoff point of NLR ≥5.2 (sensitivity: 93.8% and specificity: 87.8%). Kaplan–Meier curves demonstrate that patients with NLR ≤5.2 (P = 0.001) and BNP <1000 pg/dl (P < 0.0001) presented greater survival. Conclusions: NLR (≥5.2) and lymphopenia (≤1000 lymphocyte/μL) were associated with a poor prognosis and a higher chance of evolution to death or cardiac transplant, similar to the findings for BNP. |
Abstract: | Objetivo: O objetivo deste estudo é avaliar a relação neutrófilos-linfócitos (RNL) e plaquetas-linfócitos, a partir de hemogramas obtidos de crianças e adolescentes com cardiomiopatia dilatada (CMD), e correlacioná-los com os níveis da doença tipo B. peptídeo natriurético (BNP) e com a evolução clínica desses pacientes a longo prazo. Materiais e métodos: O acompanhamento de 57 pacientes com CMD foi feito retrospectivamente, com hemograma e dosagem de BNP após terapia otimizada para insuficiência cardíaca. Comparamos os achados dos exames dos pacientes que evoluíram com estabilidade em relação à ocorrência de listagem de transplante, transplante cardíaco ou evolução para óbito. Resultados: A idade média foi de 48 meses e o seguimento foi de 64 meses. A média dos níveis de neutrófilos foi maior no grupo de má evolução (7026 vs. 3903; P = 0,011) assim como a média de NLR (5,5 vs. 1,9; P = 0,034). As médias de hemoglobina, leucócitos totais, linfócitos e plaquetas foram semelhantes nos grupos. A área sob a curva característica de operação do receptor para NLR em relação à má evolução foi de 72,9%, sendo o melhor ponto de corte de NLR ≥5,2 (sensibilidade: 93,8% e especificidade: 87,8%). As curvas de Kaplan-Meier demonstram que pacientes com NLR ≤5,2 (P = 0,001) e BNP <1000 pg/dl (P < 0,0001) apresentaram maior sobrevida. Conclusões: NLR (≥5,2) e linfopenia (≤1.000 linfócitos/μL) foram associados a pior prognóstico e maior chance de evolução para óbito ou transplante cardíaco, semelhante aos achados para BNP. |
Subject: | Cardiomiopatia dilatada Insuficiência cardíaca Contagem de linfócitos Contagem de neutrófilos Prognóstico |
language: | eng |
metadata.dc.publisher.country: | Brasil |
Publisher: | Universidade Federal de Minas Gerais |
Publisher Initials: | UFMG |
metadata.dc.publisher.department: | MEDICINA - FACULDADE DE MEDICINA |
Rights: | Acesso Aberto |
metadata.dc.identifier.doi: | 10.4103/apc.APC_47_18 |
URI: | http://hdl.handle.net/1843/39593 |
Issue Date: | 2019 |
metadata.dc.url.externa: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343383/ |
metadata.dc.relation.ispartof: | Annals of Pediatric Cardiology |
Appears in Collections: | Artigo de Periódico |
Files in This Item:
File | Description | Size | Format | |
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2019_Neutrophil-to-lymphocyte ratio used as prognostic factor marker for dilated cardiomyopathy in childhood and adolescence.pdf | 1.09 MB | Adobe PDF | View/Open |
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