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http://hdl.handle.net/1843/39632| Type: | Artigo de Periódico |
| Title: | Preliminary data of the antipancreatic tumor efficacy and toxicity of long-circulating and ph-sensitive liposomes containing cisplatin |
| Authors: | Fernanda Noal Carlesso Raquel Silva Araújo Leonardo Lima Fuscaldi Sued Eustáquio Mendes Miranda Domenico Rubello Cláudia S. Teixeira Diego Carlos dos Reis Elaine Amaral Leite Josianne N. Silveira Simone Odília Antunes Fernandes Geovanni Dantas Cassali Mônica Cristina de Oliveira Patrick M. Colletti André Luís Branco de Barros Valbert Nascimento Cardoso |
| Abstract: | Purpose Pancreatic cancer is the fourth most common cause of cancer-related death in the USA. This is mainly because of the chemoresistance of this type of tumor; thus, the development of novel therapeutic modalities is needed. Methods Long-circulating and pH-sensitive liposomes containing cisplatin (SpHL-CDDP) were administered systemically into pancreatic tumor-bearing mice for a period of 14 days. The antitumor efficacy and toxicity of this new treatment method on the basis of cisplatin-loaded liposomes was compared with the classical free-CDDP method. 99mTc-HYNIC-βAla-bombesin(7–14) tumor uptake and histopathologic findings were used to monitor and compare the two treatment modalities. Results The antitumor activity of SpHL-CDDP treatment was shown by (a) decrease in tumor volume, (b) development of tumor necrotic areas, and (c) decrease in 99mTc-HYNIC-βAla-bombesin(7–14) tumor uptake. Toxicity was evaluated by the development of inflammation and necrotic areas in the kidneys, liver, spleen, and intestine: toxic effects were greater with free-CDDP than SpHL-CDDP. Conclusion SpHL-CDDP showed significant antitumor activity in pancreatic cancer-bearing mice, with lower toxicity in comparison with free-CDDP. |
| Subject: | Toxicologia Tumor |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICB - DEPARTAMENTO DE PATOLOGIA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | 10.1097/mnm.0000000000000505 |
| URI: | http://hdl.handle.net/1843/39632 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://journals.lww.com/nuclearmedicinecomm/Abstract/2016/07000/Preliminary_data_of_the_antipancreatic_tumor.7.aspx |
| metadata.dc.relation.ispartof: | Nuclear Medicine Communications |
| Appears in Collections: | Artigo de Periódico |
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