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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/39632
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dc.creatorFernanda Noal Carlessopt_BR
dc.creatorRaquel Silva Araújopt_BR
dc.creatorLeonardo Lima Fuscaldipt_BR
dc.creatorSued Eustáquio Mendes Mirandapt_BR
dc.creatorDomenico Rubellopt_BR
dc.creatorCláudia S. Teixeirapt_BR
dc.creatorDiego Carlos dos Reispt_BR
dc.creatorElaine Amaral Leitept_BR
dc.creatorJosianne N. Silveirapt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.creatorGeovanni Dantas Cassalipt_BR
dc.creatorMônica Cristina de Oliveirapt_BR
dc.creatorPatrick M. Collettipt_BR
dc.creatorAndré Luís Branco de Barrospt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.date.accessioned2022-02-24T00:22:57Z-
dc.date.available2022-02-24T00:22:57Z-
dc.date.issued2016-
dc.citation.volume37pt_BR
dc.citation.issue7pt_BR
dc.citation.spage727pt_BR
dc.citation.epage734pt_BR
dc.identifier.doi10.1097/mnm.0000000000000505pt_BR
dc.identifier.issn01433636pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/39632-
dc.description.resumoPurpose Pancreatic cancer is the fourth most common cause of cancer-related death in the USA. This is mainly because of the chemoresistance of this type of tumor; thus, the development of novel therapeutic modalities is needed. Methods Long-circulating and pH-sensitive liposomes containing cisplatin (SpHL-CDDP) were administered systemically into pancreatic tumor-bearing mice for a period of 14 days. The antitumor efficacy and toxicity of this new treatment method on the basis of cisplatin-loaded liposomes was compared with the classical free-CDDP method. 99mTc-HYNIC-βAla-bombesin(7–14) tumor uptake and histopathologic findings were used to monitor and compare the two treatment modalities. Results The antitumor activity of SpHL-CDDP treatment was shown by (a) decrease in tumor volume, (b) development of tumor necrotic areas, and (c) decrease in 99mTc-HYNIC-βAla-bombesin(7–14) tumor uptake. Toxicity was evaluated by the development of inflammation and necrotic areas in the kidneys, liver, spleen, and intestine: toxic effects were greater with free-CDDP than SpHL-CDDP. Conclusion SpHL-CDDP showed significant antitumor activity in pancreatic cancer-bearing mice, with lower toxicity in comparison with free-CDDP.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofNuclear Medicine Communicationspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectAntitumoral efficacypt_BR
dc.subjectAntitumoral toxicitypt_BR
dc.subjectFree-cisplatinpt_BR
dc.subjectPancreatic tumorpt_BR
dc.subjectpH-sensitive liposome-containing cisplatinpt_BR
dc.subject.otherToxicologiapt_BR
dc.subject.otherTumorpt_BR
dc.titlePreliminary data of the antipancreatic tumor efficacy and toxicity of long-circulating and ph-sensitive liposomes containing cisplatinpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.lww.com/nuclearmedicinecomm/Abstract/2016/07000/Preliminary_data_of_the_antipancreatic_tumor.7.aspxpt_BR
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