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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/39764
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dc.creatorJanuária Fonseca Matospt_BR
dc.creatorLuci Maria Sant’Ana Dussept_BR
dc.creatorKarina Braga Gomes Borgespt_BR
dc.creatorRicardo Luiz Vilela de Castropt_BR
dc.creatorWendel Coura Vitalpt_BR
dc.creatorMaria das Graças Carvalhopt_BR
dc.date.accessioned2022-02-28T19:20:56Z-
dc.date.available2022-02-28T19:20:56Z-
dc.date.issued2016-
dc.citation.volume38pt_BR
dc.citation.issue3pt_BR
dc.citation.spage214pt_BR
dc.citation.epage219pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.bjhh.2016.05.011pt_BR
dc.identifier.issn1516-8484pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/39764-
dc.description.resumoBackground: The most common microcytic and hypochromic anemias are iron deficiency anemia and thalassemia trait. Several indices to discriminate iron deficiency anemia from thalassemia trait have been proposed as simple diagnostic tools. However, some of the best discriminative indices use parameters in the formulas that are only measured in modern counters and are not always available in small laboratories. The development of an index with good diagnostic accuracy based only on parameters derived from the blood cell count obtained using simple counters would be useful in the clinical routine. Thus, the aim of this study was to develop and validate a discriminative index to differentiate iron deficiency anemia from thalassemia trait. Methods: To develop and to validate the new formula, blood count data from 106 (thalassemia trait: 23 and iron deficiency: 83) and 185 patients (thalassemia trait: 30 and iron deficiency: 155) were used, respectively. Iron deficiency, β-thalassemia trait and α-thalassemia trait were confirmed by gold standard tests (low serum ferritin for iron deficiency anemia, HbA2 > 3.5% for β-thalassemia trait and using molecular biology for the α-thalassemia trait). Results: The sensitivity, specificity, efficiency, Youden’s Index, area under receiver operating characteristic curve and Kappa coefficient of the new formula, called the Matos & Carvalho Index were 99.3%, 76.7%, 95.7%, 76.0, 0.95 and 0.83, respectively. Conclusion: The performance of this index was excellent with the advantage of being solely dependent on the mean corpuscular hemoglobin concentration and red blood cell count obtained from simple automatic counters and thus may be of great value in underdeveloped and developing countries.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRevista Brasileira de Hematologia e Hemoterapiapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectIron deficiency anemiapt_BR
dc.subjectThalassemia traitpt_BR
dc.subjectNew indexpt_BR
dc.subject.otherAnemia ferroprivapt_BR
dc.subject.otherTalassemiapt_BR
dc.subject.otherHematologiapt_BR
dc.titleA new index to discriminate between iron deficiency anemia and thalassemia traitpt_BR
dc.typeArtigo de Periódicopt_BR
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