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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/39905
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dc.creatorKarine Araújo Damascenopt_BR
dc.creatorEnio Ferreirapt_BR
dc.creatorAlessandra Estrela da Silva Limapt_BR
dc.creatorConrado de Oliveira Gambapt_BR
dc.creatorFernanda Freitas Mirandapt_BR
dc.creatorMariana Rezende Alvespt_BR
dc.creatorRafael Malagoli Rochapt_BR
dc.creatorAndré Luís Branco de Barrospt_BR
dc.creatorGeovanni Dantas Cassalipt_BR
dc.date.accessioned2022-03-09T18:59:07Z-
dc.date.available2022-03-09T18:59:07Z-
dc.date.issued2016-08-04-
dc.citation.volume11pt_BR
dc.citation.issue8pt_BR
dc.citation.spage1pt_BR
dc.citation.epage14pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0160419pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/39905-
dc.description.resumoVersican expression promotes tumor growth by destabilizing focal cell contacts, thus impeding cell adhesion and facilitating cell migration. It not only presents or recruits molecules to the cell surface, but also modulates gene expression levels and coordinates complex signal pathways. Previously, we suggested that the interaction between versican and human epidermal growth factor receptors may be directly associated with tumor aggressiveness. Thus, the expression of EGFR and HER-2 in these neoplasms may contribute to a better understanding of the progression mechanisms in malignant mammary tumors. The purpose of this study was to correlate the gene and protein expressions of EGFR and HER2 by RNA In Situ Hybridization (ISH) and immunohistochemistry (IHC), respectively, and their relationship with the versican expression in carcinomas in mixed tumors and carcinosarcomas of the canine mammary gland. The results revealed that EGFR mRNA expression showed a significant difference between in situ and invasive carcinomatous areas in low and high versican expression groups. Identical results were observed in HER-2 mRNA expression. In immunohistochemistry analysis, neoplasms with low versican expression. showed greater EGFR immunostaining in the in situ areas than in invasive areas, even as the group presenting high versican expression displayed greater EGFR and HER-2 staining in in situ areas. Significant EGFR and HER-2 mRNA and protein expressions in in situ carcinomatous sites relative to invasive areas suggest that these molecules play a role during the early stages of tumor progression.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPlos Onept_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherNeoplasias mamárias animaispt_BR
dc.subject.otherVersicanaspt_BR
dc.subject.otherReceptores de superfície celularpt_BR
dc.subject.otherHibridização in situpt_BR
dc.subject.otherGenes ErbBpt_BR
dc.subject.otherTumor misto malignopt_BR
dc.subject.otherMetástase neoplásicapt_BR
dc.titleHER-2 and EGFR mRNA expression and its relationship with Versican in malignant matrix-producing tumors of the canine mammary glandpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160419pt_BR
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