Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/40162| Type: | Artigo de Periódico |
| Title: | Clinical response to donepezil in mild and moderate dementia: relationship to drug plasma concentration and CYP2D6 and APOE genetic polymorphisms |
| Authors: | Luís Felipe José Ravic de Miranda Karina Braga Gomes Borges Pedro Augusto Lopes Tito Josianne Nicácio Silveira Gerson Antônio Pianetti Ricardo Martins Duarte Byrro Patrícia Regina Henrique Peles Fernando Henrique Pereira Thiago Rezende dos Santos Arthur Goncalves Assini Valéria Valadares Ribeiro Edgar Nunes de Moares Paulo Caramelli |
| Abstract: | The clinical response to donepezil in patients with mild and moderate dementia was investigated in relation to the drug plasma concentration and APOE and CYP2D6 polymorphisms. In a prospective naturalistic observational study, 42 patients with Alzheimer’s disease (AD) and AD with cerebrovascular disease who took donepezil (10 mg) for 12 months were evaluated. Their DNA was genotyped, and the donepezil plasma concentrations were measured after 3, 6, and 12 months. Good responders scored ≥–1 on the Mini-Mental State Examination at 12 months in comparison to the baseline score. The study results indicated the good response pattern was influenced by the concentration of donepezil, but not by APOE and CYP2D6 polymorphisms. |
| Subject: | Doença de Alzheimer Demência Apolipoproteínas E Citocromo P-450 CYP2D6 Donepezila Genética |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICX - DEPARTAMENTO DE ESTATÍSTICA MED - DEPARTAMENTO DE ANATOMIA E IMAGEM MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | 10.3233/JAD-160164 |
| URI: | http://hdl.handle.net/1843/40162 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://content.iospress.com/articles/journal-of-alzheimers-disease/jad160164 |
| metadata.dc.relation.ispartof: | Journal of Alzheimer's Disease |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.