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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/40167
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dc.creatorCaroline Pereira Dominguetipt_BR
dc.creatorLuci Maria SantAna Dussept_BR
dc.creatorMaria das Graças Carvalhopt_BR
dc.creatorLirlândia Pires de Sousapt_BR
dc.creatorKarina Braga Gomes Borgespt_BR
dc.creatorAna Paula Salles Moura Fernandespt_BR
dc.date.accessioned2022-03-16T20:43:57Z-
dc.date.available2022-03-16T20:43:57Z-
dc.date.issued2016-
dc.citation.volume30pt_BR
dc.citation.issue4pt_BR
dc.citation.spage738pt_BR
dc.citation.epage745pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jdiacomp.2015.12.018pt_BR
dc.identifier.issn1056-8727pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40167-
dc.description.resumoBackground: Vascular complications are the leading cause of morbidity and mortality among patients with type 1 and type 2 diabetes mellitus. These vascular abnormalities result of a chronic hyperglycemic state, which leads to an increase in oxidative stress and inflammatory responses. Aim: This review addresses the relationships among endothelial dysfunction, hypercoagulability and inflammation and their biomarkers in the development of vascular complications in type 1 and type 2 diabetes. Results: Inflammation, endothelial dysfunction, and hypercoagulability are correlated to each other, playing an important role in the development of vascular complications in diabetic patients. Moreover, it has been observed that several endothelial, inflammatory and pro-coagulant biomarkers, such as VWF, IL-6, TNF-α, D-dimer and PAI-1, are increased in diabetic patients who have microvascular and macrovascular complications, including nephropathy or cardiovascular disease. Conclusion: It is promising the clinical and laboratory use of endothelial, inflammatory and pro-coagulant biomarkers for predicting the risk of cardiovascular and renal complications in diabetic patients and for monitoring these patients.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Diabetes and its Complicationspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectDiabetes mellituspt_BR
dc.subjectVascular complicationspt_BR
dc.subjectEndothelial dysfunctionpt_BR
dc.subjectHypercoagulabilitypt_BR
dc.subjectInflammationpt_BR
dc.subject.otherDiabetes mellituspt_BR
dc.subject.otherAngiopatias diabéticaspt_BR
dc.subject.otherTrombofiliapt_BR
dc.subject.otherEstresse oxidativopt_BR
dc.subject.otherInflamaçãopt_BR
dc.titleDiabetes mellitus: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complicationspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S1056872715005073#ab0005pt_BR
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