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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/40176
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dc.creatorKathryna Fontana Rodriguespt_BR
dc.creatorNathalia Teixeira Pietranipt_BR
dc.creatorAdriana Aparecida Boscopt_BR
dc.creatorCláudia Natália Ferreirapt_BR
dc.creatorKarina Braga Gomes Borgespt_BR
dc.date.accessioned2022-03-17T13:58:04Z-
dc.date.available2022-03-17T13:58:04Z-
dc.date.issued2016-
dc.citation.volume13pt_BR
dc.citation.issue3pt_BR
dc.citation.spage152pt_BR
dc.citation.epage155pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.apme.2016.02.010pt_BR
dc.identifier.issn0976-0016pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40176-
dc.description.resumoBackground/aims: Irisin is a hormone expressed in muscle, which is an exercise-induced myokine triggering browning of white adipose tissue and increases metabolic genes expression. Methods: We investigated the irisin levels in 39 type 2 diabetes mellitus patients (T2D) compared to 39 control individuals.Results: Irisin plasma levels were higher in T2D patients when compared with the control group (p < 0.0001). Non-obese T2D individuals presented higher irisin levels when compared with non-obese and obese controls (p < 0.0001 and p = 0.011, respectively). Obese T2D individuals showed higher irisin levels when compared with non-obese control (p = 0.003), but no difference was observed when compared with obese controls (p > 0.05). A positive correlation was observed between irisin and fasting glucose levels in the T2D group (r = 0.341, p = 0.033). No difference regarding irisin levels was found when T2D individuals who practice physical activity and sedentary individuals were compared (p = 0.632). Conclusion: This result indicates that T2D is associated with an irisin release in order to compensate the insulin resistance observed in the skeletal muscle on diabetes, and that the poor glycaemic control contributes for enhancement of this state.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofApollo Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectIrisinpt_BR
dc.subjectType 2 diabetes mellituspt_BR
dc.subjectObesitypt_BR
dc.subjectGlucose metabolismpt_BR
dc.subjectPhysical activitypt_BR
dc.subject.otherDiabetes mellitus tipo 2pt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherGlucosept_BR
dc.subject.otherMetabolismopt_BR
dc.subject.otherExercício físicopt_BR
dc.titleCirculating irisin is increased in type 2 diabetes mellitus and correlates with fasting glucose levelspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S0976001616000259pt_BR
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