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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/40274
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dc.creatorManuelle Maria Pereira Natividadept_BR
dc.creatorCaroline Pereira Dominguetipt_BR
dc.creatorAna Paula Salles Moura Fernandespt_BR
dc.creatorRodrigo Bastos Fóscolopt_BR
dc.creatorJanice Sepúlveda Reispt_BR
dc.creatorLuci Maria SantAna Dussept_BR
dc.creatorCamila Stefanie Fonseca de Oliveirapt_BR
dc.creatorJoão Paulo Amaral Haddadpt_BR
dc.creatorLara Carvalho Godoipt_BR
dc.creatorKarina Braga Gomes Borgespt_BR
dc.creatorHenrique Pimenta Barroso Magalhãespt_BR
dc.date.accessioned2022-03-21T16:05:09Z-
dc.date.available2022-03-21T16:05:09Z-
dc.date.issued2016-
dc.citation.volume15pt_BR
dc.citation.issue3pt_BR
dc.citation.spage1pt_BR
dc.citation.epage14pt_BR
dc.identifier.doihttps://doi.org/10.9734/BJMMR/2016/23476pt_BR
dc.identifier.issn2231-0614pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40274-
dc.description.resumoIntroduction: It is known that laboratorial tests (urinary albumin excretion and glomerular filtration rate), routinely used for nephropathy diagnosis in type 1 diabetes (T1DM), have limitations that justify the evaluation of new renal biomarkers. This study assessed the performance of cystatin C, alkaline phosphatase (AP) and gamma-glutamyl transferase (GGT) for nephropathy diagnosis in T1DM patients. The reduction of economic cost and increase in sensibility and specificity from correct biochemical diagnosis of diabetic nephropathy is an important objective of this work. Methods: Cystatin C, AP and GGT were determined in plasma and urine of healthy individuals (N=35) and T1DM patients with (N=45) and without nephropathy (N=80). Results: The plasma levels of cystatin C, AP and GGT, as well as urinary levels of cystatin C and AP were able to differentiate diabetic patients with and without nephropathy. Plasma cystatin C better followed the progression of albuminuria. Cystatin C and AP discriminated the onset of nephropathy in T1DM patients better than creatinine. AP plasma/urine ratio progressively increased from the controls to the diabetic patients without and with nephropathy. Conclusion: The plasma levels of cystatin C and AP may be useful, with the classical markers of renal function, for nephropathy diagnosis and monitoring in T1DM patients.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBritish Journal of Medicine and Medical Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDiabetic nephropathypt_BR
dc.subjectCystatin Cpt_BR
dc.subjectAlkaline phosphatasept_BR
dc.subjectGamma-glutamyl transferasept_BR
dc.subject.otherNefropatias diabéticaspt_BR
dc.subject.otherDiabetes mellituspt_BR
dc.subject.otherCistatina Cpt_BR
dc.subject.otherFosfatase alcalinapt_BR
dc.subject.otherGama-glutamiltransferasept_BR
dc.titlePerformance of new biomarkers of nephropathy in patients with type 1 diabetes mellituspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.journaljammr.com/index.php/JAMMR/article/view/10278pt_BR
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