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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/40580
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dc.creatorRachel Lima Marcelino Freirept_BR
dc.creatorMaria Betânia de Freitas Marquespt_BR
dc.creatorElaine Maria de Souza-Fagundespt_BR
dc.creatorRenata Barbosa de Oliveirapt_BR
dc.creatorRicardo José Alvespt_BR
dc.date.accessioned2022-03-29T21:07:31Z-
dc.date.available2022-03-29T21:07:31Z-
dc.date.issued2017-
dc.citation.volume53pt_BR
dc.citation.issue1pt_BR
dc.citation.spage1pt_BR
dc.citation.epage7pt_BR
dc.identifier.doi10.1590/s2175-97902017000115235pt_BR
dc.identifier.issn19848250pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40580-
dc.description.resumoA novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromolar concentrations, against all the assayed tumor cell lines. Compound 3 was selected for further studies in mice with Ehrlich solid tumors and it was able to reduce the rate of tumor growth significantly during the first seven days. However, at the end of the experiments, there was no significant difference between the group of animals treated with 3 and the control group. The low solubility of the compound in the assay conditions can explain, at least in part, these results.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCytotoxic activitypt_BR
dc.subjectPlatinum complexespt_BR
dc.subjectEhrlich solid tumor activitypt_BR
dc.subject.otherComplexos de platinapt_BR
dc.subject.otherAtividade citotóxicapt_BR
dc.titleSynthesis and evaluation of platinum complexes with potential antitumor activitypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bjps/a/phzPyCQnkc5yWpyyHtrPcky/?lang=enpt_BR
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