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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/40631
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dc.creatorLuciana Flávia de Almeida Romanipt_BR
dc.creatorMaria Irene Yoshidapt_BR
dc.creatorElionai Cassiana de Lima Gomespt_BR
dc.creatorRenes de Resende Machadopt_BR
dc.creatorFelipe Fernandes Rodriguespt_BR
dc.creatorMárcio de Matos Coelhopt_BR
dc.creatorMarcelo Antônio de Oliveirapt_BR
dc.creatorMaria Betânia de Freitas-Marquespt_BR
dc.creatorRosane Aguiar da Silva San Gilpt_BR
dc.creatorWagner da Nova Musselpt_BR
dc.date.accessioned2022-03-30T20:07:51Z-
dc.date.available2022-03-30T20:07:51Z-
dc.date.issued2018-04-
dc.citation.volume8pt_BR
dc.citation.issue2pt_BR
dc.citation.spage103pt_BR
dc.citation.epage108pt_BR
dc.identifier.doi10.1016/j.jpha.2017.12.006pt_BR
dc.identifier.issn20951779pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40631-
dc.description.resumoMeloxicam (MLX) is an anti-inflammatory drug susceptible to variations and crystalline transitions. In compounding pharmacies, the complete crystallographic evaluation of the raw material is not a routine procedure. We performed a complete crystallographic characterization of aleatory raw MLX samples from compounding pharmacies. X-ray diffraction indicated the presence of two crystalline forms in one sample. DSC experiments suggested that crystallization, or a crystal transition, occurred differently between samples. The FTIR and 1H NMR spectra showed characteristic assignments. 13C solid-state NMR spectroscopy indicated the presence of more than one phase in a sample from pharmacy B. The Hirshfeld surface analysis, with electrostatic potential projection, allowed complete assignment of the UV spectra in ethanol solution. The polymorph I of meloxicam was more active than polymorph III in an experimental model of acute inflammation in mice. Our results highlighted the need for complete crystallographic characterization and the separation of freely used raw materials in compounding pharmacies, as a routine procedure, to ensure the desired dose/effect.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Pharmaceutical Analysispt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMeloxicampt_BR
dc.subjectPolymorphismpt_BR
dc.subjectHirshfeld surfacept_BR
dc.subjectAnti-inflammatory activitypt_BR
dc.subject.otherQuímicapt_BR
dc.subject.otherFarmácia de manipulaçãopt_BR
dc.subject.otherFarmáciapt_BR
dc.titlePhysicochemical characterization, the hirshfeld surface, and biological evaluation of two meloxicam compounding pharmacy samplespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2095177917301399pt_BR
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