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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/40752
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dc.creatorMaria Betânia de Freitas Marquespt_BR
dc.creatorBárbara Caroline Rodrigues de Araújopt_BR
dc.creatorChristian Fernandespt_BR
dc.creatorMaria Irene Yoshidapt_BR
dc.creatorWagner da Nova Musselpt_BR
dc.creatorRita de Cássia de Oliveira Sebastiãopt_BR
dc.date.accessioned2022-04-04T21:52:07Z-
dc.date.available2022-04-04T21:52:07Z-
dc.date.issued2020-
dc.citation.volume31pt_BR
dc.citation.issue3pt_BR
dc.citation.spage512pt_BR
dc.citation.epage522pt_BR
dc.identifier.doi10.21577/0103-5053.20190211pt_BR
dc.identifier.issn0103-5053pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40752-
dc.description.resumoThermal analysis can be used to determine shelf-life and kinetic parameters in pharmaceutical systems. This work investigates the kinetic of lumefantrine thermal decomposition, an antimalarial, using non-isothermal and isothermal experimental data. The non-isothermal conditions are analyzed applying Vyazovkin method, while isothermal conditions employ models fitting procedure and artificial neural network. Lumefantrine was characterized by powder X-ray diffraction and Fourier transform infrared spectroscopy. The initial stage of lumefantrine thermal decomposition, about 5% of conversion, corresponds to the loss of chlorine and hydroxyl, being correctly predicted by the neural network as a complex event. At room temperature, the D3 model is appropriate to describe the process, once the half-life time is 19 months, in agreement with manufacturer. Isoconversional model determined the activation energy along the whole process while isothermal methodology determined the global value considering the entire process. The results provide important information for the pharmaceutical industry to assay levels of acceptable lumefantrine contents.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of the Brazilian Chemical Societypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSolid thermal stabilitypt_BR
dc.subjectAntimalarial drugpt_BR
dc.subjectKinetic tripletpt_BR
dc.subjectThermogravimetrypt_BR
dc.subjectMultilayer perceptron networkpt_BR
dc.subject.otherLumefantrinapt_BR
dc.subject.otherAntimaláricopt_BR
dc.subject.otherCinética da decomposição térmicapt_BR
dc.titleKinetics of lumefantrine thermal decomposition employing isoconversional models and artificial neural networkpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/jbchs/a/bBmxxMZzr8zNQyfLHbJVM5F/?lang=enpt_BR
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