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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/40843
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dc.creatorRoberta Cristelli Fonsecapt_BR
dc.creatorGabriel Shimizu Bassipt_BR
dc.creatorCamila Carvalho Britopt_BR
dc.creatorLorena Barreto Rosapt_BR
dc.creatorBruna Araújo Davidpt_BR
dc.creatorAlan Moreira Araújopt_BR
dc.creatorNatália Nóbregapt_BR
dc.creatorAriane Barros Dinizpt_BR
dc.creatorItamar Couto Guedes Jesuspt_BR
dc.creatorLucíola Silva Barcelospt_BR
dc.creatorMarco Antônio Peliky Fontespt_BR
dc.creatorDaniella Bonaventurapt_BR
dc.creatorAlexandre Kanashiropt_BR
dc.creatorThiago Mattar Cunhapt_BR
dc.creatorSílvia Guatimosimpt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.creatorGustavo Batista Menezespt_BR
dc.creatorGuillaume de Lartiguept_BR
dc.creatorAndré Gustavo Oliveirapt_BR
dc.date.accessioned2022-04-06T21:26:56Z-
dc.date.available2022-04-06T21:26:56Z-
dc.date.issued2019-10-
dc.citation.volume81pt_BR
dc.citation.spage444pt_BR
dc.citation.epage454pt_BR
dc.identifier.doi10.1016/j.bbi.2019.06.041pt_BR
dc.identifier.issn0889-1591pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40843-
dc.description.resumoThe gastrointestinal (GI) tract harbors commensal microorganisms as well as invasive bacteria, toxins and other pathogens and, therefore, plays a pivotal barrier and immunological role against pathogenic agents. The vagus nerve is an important regulator of the GI tract-associated immune system, having profound effects on inflammatory responses. Among GI tract organs, the liver is a key site of immune surveillance, as it has a large population of resident macrophages and receives the blood drained from the guts through the hepatic portal circulation. Although it is widely accepted that the hepatic tissue is a major target for vagus nerve fibers, the role of this neural circuit in liver immune functions is still poorly understood. Herein we used in vivo imaging techniques, including confocal microscopy and scintigraphy, to show that vagus nerve stimulation increases the phagocytosis activity by resident macrophages in the liver, even on the absence of an immune challenge. The activation of this neural circuit in a non-lethal model of sepsis optimized the removal of bacteria in the liver and resulted in the production of anti-inflammatory and pro-regenerative cytokines. Our findings provide new insights into the neural regulation of the immune system in the liver.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrain, Behavior, and Immunitypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectVagus nervept_BR
dc.subjectCholinergic signalingpt_BR
dc.subjectLiverpt_BR
dc.subjectKupffer cellspt_BR
dc.subjectPhagocytosispt_BR
dc.subject.otherFígadopt_BR
dc.subject.otherNervo vagopt_BR
dc.titleVagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liverpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S088915911831225X?via%3Dihubpt_BR
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