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http://hdl.handle.net/1843/40931| Type: | Artigo de Periódico |
| Title: | Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic review |
| Authors: | Rafael Coelho Magalhães Letícia Pereira Pimenta Izabela Guimarães Barbosa Janaina Matos Moreira João Luís Vieira Monteiro de Barros Antonio Lucio Teixeira Ana Cristina Simões e Silva |
| Abstract: | To provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. Data Source: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth. Data synthesis: 11 eligible studies clearly investigated the association between peripheral inflammation and motor and/or cognitive development in preterm infants. However, the selected populations differed in relation to the events associated with prematurity and the risk factors to abnormal motor and/or cognitive development. These studies measured circulating levels of cytokines, chemokines, adhesion molecules, acute phase proteins, and growth factors. The most commonly analyzed proteins were IL-1β, IL-6, TNF, CCL5/RANTES, CXCL8/IL-8, IGFBP-1, and VEGF. In seven of the eligible studies, plasma levels of IL-6 correlated with development delay. Two studies reported correlation between CXCL8/IL-8 plasma levels with cognitive and motor delay. In one study, higher levels of MCP-1/CCL2 were associated with better cognitive and motor outcome. Conclusion: There is preliminary evidence indicating that circulating inflammatory molecules are associated with motor and cognitive development in preterm neonates, even considering different populations. |
| Subject: | Inflamação Citocinas Desempenho psicomotor Desenvolvimento cognitivo Prematuros |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | EEF - DEPARTAMENTO DE TERAPIA OCUPACIONAL MED - DEPARTAMENTO DE PEDIATRIA MED - DEPARTAMENTO DE SAÚDE MENTAL |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.ijdevneu.2017.10.006 |
| URI: | http://hdl.handle.net/1843/40931 |
| Issue Date: | Apr-2018 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/full/10.1016/j.ijdevneu.2017.10.006 |
| metadata.dc.relation.ispartof: | International Journal of Developmental Neuroscience |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates.pdf | 386.76 kB | Adobe PDF | View/Open |
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