1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/40931
Full metadata record
DC FieldValueLanguage
dc.creatorRafael Coelho Magalhãespt_BR
dc.creatorLetícia Pereira Pimentapt_BR
dc.creatorIzabela Guimarães Barbosapt_BR
dc.creatorJanaina Matos Moreirapt_BR
dc.creatorJoão Luís Vieira Monteiro de Barrospt_BR
dc.creatorAntonio Lucio Teixeirapt_BR
dc.creatorAna Cristina Simões e Silvapt_BR
dc.date.accessioned2022-04-08T14:47:50Z-
dc.date.available2022-04-08T14:47:50Z-
dc.date.issued2018-04-
dc.citation.volume65pt_BR
dc.citation.spage29pt_BR
dc.citation.epage37pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ijdevneu.2017.10.006pt_BR
dc.identifier.issn1873-474Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/40931-
dc.description.resumoTo provide a systematic review investigating the role of inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates. Data Source: Databases including PubMed, BIREME, and Scopus were systematically searched. Observational studies, as well as transversal, and cohort studies using human subjects published from 1990 to September 2017 were eligible for inclusion. Two authors independently identified eligible studies and analyzed their characteristics, quality, and accuracy in depth. Data synthesis: 11 eligible studies clearly investigated the association between peripheral inflammation and motor and/or cognitive development in preterm infants. However, the selected populations differed in relation to the events associated with prematurity and the risk factors to abnormal motor and/or cognitive development. These studies measured circulating levels of cytokines, chemokines, adhesion molecules, acute phase proteins, and growth factors. The most commonly analyzed proteins were IL-1β, IL-6, TNF, CCL5/RANTES, CXCL8/IL-8, IGFBP-1, and VEGF. In seven of the eligible studies, plasma levels of IL-6 correlated with development delay. Two studies reported correlation between CXCL8/IL-8 plasma levels with cognitive and motor delay. In one study, higher levels of MCP-1/CCL2 were associated with better cognitive and motor outcome. Conclusion: There is preliminary evidence indicating that circulating inflammatory molecules are associated with motor and cognitive development in preterm neonates, even considering different populations.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE TERAPIA OCUPACIONALpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Journal of Developmental Neurosciencept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectInflammationpt_BR
dc.subjectCytokinespt_BR
dc.subjectNeurotrophic factorspt_BR
dc.subjectMotor developmentpt_BR
dc.subjectCognitive developmentpt_BR
dc.subjectPretermpt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherCitocinaspt_BR
dc.subject.otherDesempenho psicomotorpt_BR
dc.subject.otherDesenvolvimento cognitivopt_BR
dc.subject.otherPrematurospt_BR
dc.titleInflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates: a systematic reviewpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1016/j.ijdevneu.2017.10.006pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-8960-2256pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0003-0074-3034pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-9621-5422pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9222-3882pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Inflammatory molecules and neurotrophic factors as biomarkers of neuropsychomotor development in preterm neonates.pdf386.76 kBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.