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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41123
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dc.creatorJuliana Vilela Bastospt_BR
dc.creatorTarcilia Silvapt_BR
dc.creatorEnrico Colosimopt_BR
dc.creatorMaria Ilma Cortêspt_BR
dc.creatorDaniela Augusta Ferreirapt_BR
dc.creatorEugênio Marcos Goulartpt_BR
dc.creatorRicardo Gomespt_BR
dc.creatorWalderez Dutrapt_BR
dc.date.accessioned2022-04-21T00:36:06Z-
dc.date.available2022-04-21T00:36:06Z-
dc.date.issued2017-02-
dc.citation.volume43pt_BR
dc.citation.spage203pt_BR
dc.citation.epage209pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.joen.2016.10.018pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41123-
dc.description.resumoIntroduction The progressive forms of inflammatory external root resorption (IERR) and replacement external root resorption (RERR) are serious complications and the main causes of tooth loss after replantation. This study aimed to investigate the expression pattern of inflammatory molecules in extracted human teeth presenting with external root resorption (ERR) after replantation. Methods Root fragments from 22 teeth showing IERR and 20 teeth with RERR were triturated using a homogenizer to extract inflammatory molecules. Interleukin-1β (IL-1β), IL-1Ra, transforming growth factor beta, IL-8/CXCL8, CCL2, CCL3, and CCL5 were measured using double-ligand enzyme-linked immunosorbent assay, and IL-2, IL-4, IL-6, IL-10, tumor necrosis factor alpha, interferon gamma, and IL-17A detection was performed using the multiplex Th1/Th2/Th17 Cytometric Bead Array kit (BD Biosciences, San Jose, CA). Cytokine and chemokine concentrations were compared in the RERR and IERR groups corrected by patients' age at the moment of extraction, survival time after replantation, and index of ERR, adopting a generalized estimation equation model. Results The IERR group showed higher levels of tumor necrosis factor alpha than the RERR group, even after correction for the index of ERR (P < .05). IL-1Ra levels were higher in the IERR group for moderate cases but higher in the RERR group for severe cases (P < .05). IL-4 concentration became higher with the increase of patients' age in the RERR group but did not vary in the IERR group (P < .05). CCL2 levels decreased with the increase of the patients' age at the moment of extraction irrespective of the type or index of ERR (P < .05). Conclusions The present results showed differences in the immunologic profile of IERR and RERR that may be relevant to understanding the biological mechanisms underlying ERRpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE ESTATÍSTICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Endodonticspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectAvulsionpt_BR
dc.subjectChemokinespt_BR
dc.subjectCytokinespt_BR
dc.subjectInflammatory external root resorptionpt_BR
dc.subjectReplacement external root resorptionpt_BR
dc.subjectReplantationpt_BR
dc.subject.otherTooth avulsionpt_BR
dc.subject.otherInterleukin-8pt_BR
dc.subject.otherCytokinespt_BR
dc.subject.otherRoot resorptionpt_BR
dc.subject.otherReplantationpt_BR
dc.titleExpression of inflammatory cytokines and chemokines in replanted permanent teeth with external root resorptionpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0099239916307452?via%3Dihubpt_BR
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