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http://hdl.handle.net/1843/41298| Type: | Artigo de Periódico |
| Title: | Radionuclide imaging in chagas cardiomyopathy |
| Authors: | Marcus Vinicius Simões Leonardo Pippa Gadioli Luciano Fonseca Lemos de Oliveira |
| Abstract: | Purpose of Review: To review the contributions of radionuclide imaging to understanding the manifestations and pathophysiology of chronic Chagas cardiomyopathy (CCC). Recent Findings: Experimental studies using high-resolution SPECT myocardial perfusion imaging (MPI) show that myocardial perfusion derangement that corresponds to dysfunctional, viable myocardium is closely linked to inflammation and precedes LV regional systolic dysfunction. Clinical studies show that microvascular ischemia is strictly related to the areas of cardiac sympathetic denervation, assessed by 123I-MIBG imaging, which correlates with severe ventricular arrhythmia incidence. Initial case reports suggest that 18F-FDG-PET imaging is a promising, non-invasive detection method for myocardial inflammation. Summary: Available evidence indicates that microvascular ischemia participates in the mechanisms causing myocardial injury in CCC, with potential implication for monitoring subclinical disease progression. Moreover, MIBG imaging is a promising tool for risk stratification of sudden death. Preliminary clinical experience suggests a role for 18F-FDG-PET in detection of inflammation in CCC. |
| Subject: | Doença de Chagas Cardiomiopatia chagásica Diagnóstico por imagem Cintilografia Reperfusão miocárdica Miocardite |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | EEF - DEPARTAMENTO DE FISIOTERAPIA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1007/s12410-019-9482-8 |
| URI: | http://hdl.handle.net/1843/41298 |
| Issue Date: | Feb-2019 |
| metadata.dc.url.externa: | https://link.springer.com/article/10.1007/s12410-019-9482-8#author-information |
| metadata.dc.relation.ispartof: | Current Cardiovascular Imaging Reports |
| Appears in Collections: | Artigo de Periódico |
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