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http://hdl.handle.net/1843/41440| Type: | Artigo de Periódico |
| Title: | Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice |
| Authors: | Diego dos Santos Ferreira Bruno Luís Jesus de Oliveira Pinto Vidhya Kumar Valbert Nascimento Cardoso Simone Odília Fernandes Cristina Maria Souza Geovanni Dantas Cassali Anna Moore David Edwin Sosnovik Christian Taylor Farrar Elaine Amaral Leite Ricardo José Alves Mônica Cristina de Oliveira Alexander Ramos Guimarães Peter Caravan |
| Abstract: | Chemotherapy for bone tumors is a major challenge because of the inability of therapeutics to penetrate dense bone mineral. We hypothesize that a nanostructured formulation with high affinity for bone could deliver drug to the tumor while minimizing off-target toxicity. Here, we evaluated the efficacy and toxicity of a novel bone-targeted, pH-sensitive liposomal formulation containing doxorubicin in an animal model of bone metastasis. Biodistribution studies with the liposome showed good uptake in tumor, but low accumulation of doxorubicin in the heart. Mice treated with the bone-targeted liposome formulation showed a 70% reduction in tumor volume, compared to 35% reduction for free doxorubicin at the same dose. Both cardiac toxicity and overall mortality were significantly lower for animals treated with the bone-targeted liposomes compared to free drug. Bone-targeted, pH-sensitive, doxorubicin containing liposomes represent a promising approach to selectively delivering doxorubicin to bone tumors while minimizing cardiac toxicity. |
| Subject: | Atividade antitumoral Toxicidade cardíaca Modelo de tumor Metástase óssea Camundongos |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICB - DEPARTAMENTO DE PATOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1016/j.nano.2017.03.005 |
| URI: | http://hdl.handle.net/1843/41440 |
| Issue Date: | Jul-2017 |
| metadata.dc.url.externa: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483199/ |
| metadata.dc.relation.ispartof: | Nanomedicine: Nanotechnology, Biology and Medicine |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice.pdf | 719.29 kB | Adobe PDF | View/Open |
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