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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41472
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dc.creatorFranciellen Morais Costapt_BR
dc.creatorGabriela Almeida Bastospt_BR
dc.creatorAna Cláudia Maia Soarespt_BR
dc.creatorEvely Giovanna Leite Costapt_BR
dc.creatorViviane de Oliveira Vasconcelospt_BR
dc.creatorNeide Judith Faria de Oliveirapt_BR
dc.creatorEduardo Robson Duartept_BR
dc.creatorWalter dos Santos Limapt_BR
dc.date.accessioned2022-05-09T12:21:25Z-
dc.date.available2022-05-09T12:21:25Z-
dc.date.issued2016-06-15-
dc.citation.volume223pt_BR
dc.citation.spage43pt_BR
dc.citation.epage49pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.vetpar.2016.04.002pt_BR
dc.identifier.issn0304-4017pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41472-
dc.description.resumoAnthelminthic resistant populations of Haemonchus contortus are a major problem in sheep rearing, but plant extracts may offer viable alternative treatments. In our preliminary studies, Piptadenia viridiflora was frequently selected by sheep grazing in the Cerrado. The present research evaluated its in vitro and in vivo anthelmintic activity. The HPLC chromatograms of P. viridiflora aqueous extract (AE) and ethanolic extract (EE) showed the presence of flavonoids. The total condensed tannin (proanthocyanidin) was 0.2 and 1.01% in AE and EE, respectively. In an egg hatching inhibition (EHI) test, the LC90 of AE was 2.4 mg/mL, and, of EE, was 2.1 mg/mL. After tannin extraction, higher EHI and lower LC90 were observed. In a larval development inhibition test, the LC90 of AE was 13.66 mg/g of fecal culture. The highest dose of AE administered to mice (203.0 mg/kg bw) was well tolerated, suggesting low toxicity. In vivo, AE was orally administered to lambs at 283 mg/kg bw, and, at weeks one, two, and three post-treatment, the mean fecal egg count (FEC) was significantly lower than in untreated lambs (P < 0.05). Blood parameters were normal and similar in untreated and treated sheep. For all lamb groups, the mean total serum protein was significantly higher at week two post-treatment than at other evaluated periods (P < 0.05). Piptadenia viridiflora extracts had low condensed tannin content and exhibited high anthelminthic efficacy in vitro and significantly reduced FEC. Tannins were not shown to be the principal components affecting EHI, hence it is necessary to isolate and characterize the principal active P. viridiflora compounds, and to assess their possible synergism.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofVeterinary Parasitologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherOvinopt_BR
dc.subject.otherHaemonchus contortuspt_BR
dc.subject.otherCerradospt_BR
dc.subject.otherParasitologia veterináriapt_BR
dc.subject.otherHematologia veterináriapt_BR
dc.titleIn vitro and in vivo action of Piptadenia viridiflora (Kunth) Benth against Haemonchus contortus in sheeppt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0304401716300814?via%3Dihubpt_BR
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