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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41477
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dc.creatorDenise Mayumi Tanakapt_BR
dc.creatorLuciano Fonseca Lemos de Oliveirapt_BR
dc.creatorJosé Antonio Marin Netopt_BR
dc.creatorMinna Moreira Dias Romanopt_BR
dc.creatorEduardo Elias Vieira de Carvalhopt_BR
dc.creatorAntonio Carlos Leite de Barros Filhopt_BR
dc.creatorFernando Fonseca França Ribeiropt_BR
dc.creatorJorge Mejia Cabezapt_BR
dc.creatorCarla Duque Lopespt_BR
dc.creatorCamila Godoy Fabriciopt_BR
dc.creatorNorival Kesperpt_BR
dc.creatorHenrique Turin Moreirapt_BR
dc.creatorLauro Wichert Anapt_BR
dc.creatorAndré Schmidtpt_BR
dc.creatorMaria de Lourdes Higuchipt_BR
dc.creatorEdecio Cunha Netopt_BR
dc.creatorMarcus Vinícius Simõespt_BR
dc.date.accessioned2022-05-09T14:33:07Z-
dc.date.available2022-05-09T14:33:07Z-
dc.date.issued2019-09-
dc.citation.volume26pt_BR
dc.citation.issue5pt_BR
dc.citation.spage1569pt_BR
dc.citation.epage1579pt_BR
dc.identifier.doihttps://doi.org/10.1007/s12350-018-1198-7pt_BR
dc.identifier.issn1532-6551pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41477-
dc.description.resumoBackground: Myocardial perfusion defects (MPD) due to coronary microvascular dysfunction is frequent in chronic Chagas cardiomyopathy (CCC) and may be involved with development of myocardial damage. We investigated whether MPD precedes left ventricular systolic dysfunction and tested the hypothesis that prolonged use of dipyridamole (DIPY) could reduce MPD in an experimental model of CCC in hamsters. Methods and results: We investigated female hamsters 6-months after T. cruzi infection (baseline condition) and control animals, divided into T. cruzi-infected animals treated with DIPY (CH + DIPY) or placebo (CH + PLB); and uninfected animals treated with DIPY (CO + DIPY) or placebo (CO + PLB). The animals were submitted to echocardiogram and rest SPECT-Sestamibi-Tc99m myocardial perfusion scintigraphy. Next, the animals were treated with DIPY (4 mg/kg bid, intraperitoneal) or saline for 30 days, and reevaluated with the same imaging methods. At baseline, the CH + PLB and CH + DIPY groups showed larger areas of perfusion defect (13.2 ± 13.2% and 17.3 ± 13.2%, respectively) compared with CO + PLB and CO + DIPY (3.8 ± 2.2% e 3.5 ± 2.7%, respectively), P < .05. After treatment, we observed: reduction of perfusion defects only in the CH + DIPY group (17.3 ± 13.2% to 6.8 ± 7.6%, P = .001) and reduction of LVEF in CH + DIPY and CH + PLB groups (from 65.3 ± 9.0% to 53.6 ± 6.9% and from 69.3 ± 5.0% to 54.4 ± 8.6%, respectively, P < .001). Quantitative histology revealed greater extents of inflammation and interstitial fibrosis in both Chagas groups, compared with control group (P < .001), but no difference between Chagas groups (P > .05). Conclusions: The prolonged use of DIPY in this experimental model of CCC has reduced the rest myocardial perfusion defects, supporting the notion that those areas correspond to viable hypoperfused myocardium.pt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Nuclear Cardiologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectChagas cardiomyopathypt_BR
dc.subjectCoronary microcirculationpt_BR
dc.subjectDipyridamolept_BR
dc.subjectHamsterspt_BR
dc.subjectVentricular dysfunctionpt_BR
dc.subject.otherCardiomiopatia chagásicapt_BR
dc.subject.otherMicrocirculaçãopt_BR
dc.subject.otherCirculação coronáriapt_BR
dc.subject.otherAnimais de laboratóriopt_BR
dc.subject.otherDisfunção ventricularpt_BR
dc.titleProlonged dipyridamole administration reduces myocardial perfusion defects in experimental chronic Chagas cardiomyopathypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s12350-018-1198-7pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-5035-9172pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3455-2463pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-8651-8833pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-2526-0656pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0001-5026-335Xpt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-1182-4668pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0003-0702-5043pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-6174-6939pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0003-4076-0461pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-4543-4684pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0003-2059-5120pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-1090-8165pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-1673-6456pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-3699-3345pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-6553-8387pt_BR
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