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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41489
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dc.creatorAina Liz Alves Cesarpt_BR
dc.creatorFernanda Alves Abrantespt_BR
dc.creatorLuana Farahpt_BR
dc.creatorRachel Oliveira Castilhopt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.creatorIvana Duval de Araújopt_BR
dc.creatorAndré Augusto Gomes Faracopt_BR
dc.date.accessioned2022-05-09T20:06:45Z-
dc.date.available2022-05-09T20:06:45Z-
dc.date.issued2018-01-01-
dc.citation.volume111pt_BR
dc.citation.spage57pt_BR
dc.citation.epage64pt_BR
dc.identifier.doi10.1016/j.ejps.2017.09.037pt_BR
dc.identifier.issn0928-0987pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41489-
dc.description.resumoMesalamine (5-ASA) consists of the first-line therapy for the treatment of ulcerative colitis; however, it has low bioavailability, can cause several systemic adverse events, and has low treatment adherence due to the inconvenient dosing scheme. In this work, a new drug delivery system consisting of chondroitin sulfate linked to 5-ASA was synthesized using a carbodiimide as conjugating agent. The system was characterized by spectroscopic techniques (UV, ATR-FTIR, XRD, and NMR 1H) and thermal analysis (TG/DTG and DSC), suggesting the conjugation between the drug and the polymer. The in vitro release and the corresponding kinetics were also evaluated, revealing that approximately 40% of the drug linked was released at pH 9 for up to 50 h, following Higuchi's model. The conjugate did not show cytotoxicity for the human monocytic cell line at the doses tested, and an in vivo biodistribution study showed that the conjugate remained in the lower GIT for up to 8 h with no uptake in the upper GIT. These data corroborate with the radiation found per segment of GIT and in blood. For this last test the conjugate was radiolabeled with Technetium-99m to allow the scintigraphy evaluation and radiation quantification. In conclusion, the polymeric conjugate was successfully synthesized and demonstrated a mucoadhesiveness on the colon as desired, thus supporting its potential use in the treatment of ulcerative colitis.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CIRURGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEuropean Journal of Pharmaceutical Sciencespt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectTechnetium-99mpt_BR
dc.subjectScintigraphypt_BR
dc.subjectChondroitin sulfatept_BR
dc.subject5-Aminosalicylic acidpt_BR
dc.subjectControlled release systempt_BR
dc.subject.otherMesalazinapt_BR
dc.subject.otherCintilografiapt_BR
dc.subject.otherSistema de liberação controladapt_BR
dc.titleNew mesalamine polymeric conjugate for controlled release: preparation, characterization and biodistribution studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0928098717305274?via%3Dihubpt_BR
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