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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41626
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dc.creatorFlavia Mendes Peradeles Galdinopt_BR
dc.creatorMaria Emília Rabelo Andradept_BR
dc.creatorPatrícia Aparecida Vieira de Barrospt_BR
dc.creatorSimone de Vasconcelos Generosopt_BR
dc.creatorJacqueline Isaura Alvarez-Leitept_BR
dc.creatorCamila Megale de Almeida-Leitept_BR
dc.creatorMaria do Carmo Gouveia Peluziopt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.date.accessioned2022-05-12T21:18:30Z-
dc.date.available2022-05-12T21:18:30Z-
dc.date.issued2018-10-
dc.citation.volume49pt_BR
dc.citation.spage485pt_BR
dc.citation.epage492pt_BR
dc.identifier.doi10.1016/j.jff.2018.09.012pt_BR
dc.identifier.issn1756-4646pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41626-
dc.description.resumoMucositis is a side effect observed in patients undergoing chemotherapy. Besides, this treatment also leads to the imbalance of the intestinal microbiota. This study evaluated the effects of pre and treatment with fructo-oligosaccharides (FOS) in intestinal mucositis induced by 5-fluorouracil (5-FU). Balb/c mice were divided into four groups: CTL (without mucositis + saline), MUC (mucositis + saline), PT (mucositis + 6% FOS before disease induction) and T (mucositis + 6% FOS after disease induction). Mucositis was induced with an intraperitoneal injection of 300 mg/kg 5-FU. After 72 h intestinal permeability (IP), inflammatory infiltrate, oxidative stress, histological analysis, and short-chain fatty acids (SCFA) production were evaluated. The MUC group showed lost weight, intense inflammatory infiltrate, increased oxidative stress and IP (P < 0.05). FOS supplementation attenuated all these parameters (P < 0.05). Only pretreatment was able to maintain the acetate and butyrate production. These results showed that FOS supplementation presented protective effects on intestinal barrier function.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Functional Foodspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectMucositispt_BR
dc.subjectFructo-oligosaccharidespt_BR
dc.subject5-fluorouracilpt_BR
dc.subjectIntestinal permeabilitypt_BR
dc.subject.otherMucosite intestinalpt_BR
dc.subject.otherPermeabilidade intestinalpt_BR
dc.subject.otherfruto-oligossacarídeopt_BR
dc.subject.otherCamundongospt_BR
dc.titlePretreatment and treatment with fructo-oligosaccharides attenuate intestinal mucositis induced by 5-FU in micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1756464618304869?via%3Dihub#!pt_BR
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