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Type:	Artigo de Periódico
Title:	Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model
Authors:	Patrícia Aparecida Vieira de Barros Maria Emília Rabelo Andrade Simone de Vasconcelos Generoso Sued Eustáquio Mendes Miranda Diego Carlos dos Reis Paola Caroline Lacerda Leocádio Éricka Lorenna de Sales e Souza Flaviano dos Santos Martins Marco Antonio Sundfeld da Gama Geovanni Dantas Cassali Jacqueline Isaura Alvarez Leite Simone Odília Antunes Fernandes Valbert Nascimento Cardoso
Abstract:	Background Studies have showed the protective effects of conjugated linoleic acid (CLA) on intestinal epithelium, modulating host immune and inflammatory responses on intestinal diseases. Objective To evaluate the preventive effects of CLA on the intestinal mucositis induced by 5-FU in a murine model. Methods Sixty-four BALB/c mice were randomly divided into four groups: Control (CTL), fed a standard chow diet; CLAs, fed a diet supplemented with CLA; Mucositis (5-FU), fed a standard chow diet and underwent mucositis induction and CLAs 5-FU, fed a diet supplemented with CLA and underwent mucositis induction. Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU. After 72 h, the animals were euthanized and intestinal permeability, bacterial translocation, inflammatory mediators, and intestinal histology were evaluated. Results Mice in the CLAs 5-FU group showed reduced weight loss compared to those in the 5-FU group (p < 0.005). Furthermore, the results also showed that the treatment with CLA reduced intestinal permeability, bacterial translocation, and biomarkers of inflammatory response besides minor damage to ZO-1 and occludin with maintenance of the integrity of the intestinal epithelium and a favorable balance between the inflammatory and regulatory cytokines. Conclusion This study suggests that CLA reduced the adverse effects from 5-FU administration on the intestinal mucosa.
Subject:	Mucosite Citocinas Danos intestinais Ácido linoleico
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ENF - DEPARTAMENTO DE NUTRIÇÃO FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE MICROBIOLOGIA ICB - DEPARTAMENTO DE PATOLOGIA
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	10.1016/j.biopha.2018.04.133
URI:	http://hdl.handle.net/1843/41657
Issue Date:	Jul-2018
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S0753332218304402
metadata.dc.relation.ispartof:	Biomedicine & Pharmacotherapy
Appears in Collections:	Artigo de Periódico

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