Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/41724| Type: | Artigo de Periódico |
| Title: | Serum lipid profile as a predictor of dengue severity: a systematic review and meta-analysis |
| Authors: | William Gustavo de Lima Nayara Alves Souza Simone Odília Antunes Fernandes Valbert Nascimento Cardoso Isabella Piassi Godói |
| Abstract: | Dengue virus is known to modulate host cell lipid metabolism in order to promote efficient viral replication. Recent studies have focused on circulating lipids as potential biomarkers of dengue severity; however, the results obtained so far lack the consistency to establish a definite relationship between the two. Therefore, in the present study, we investigated serum lipids as potential biomarkers of dengue severity by conducting a meta-analysis of the currently available clinical data. Nine studies that evaluated 1,953 patients were included in the review, many of which were cross-sectional (44.4%) and conducted in Asian countries (55.5%). These studies observed the presence of lipids in serum samples (77%) of patients in the acute phase of the disease (88.8%). Circulating total-cholesterol (P = .001) and LDL (P = .001) levels, but not HDL (P = .07), VLDL (P = .9) and triglyceride (P = .57) levels, were inversely and significantly correlated with dengue severity. Total cholesterol (P ≤ .001) and LDL (P = .001) were also useful in determining the risk of hypovolemic shock in patients with severe dengue. Subgroup analysis showed that factors, such as design (cross-sectional vs cohort), racial-ethnic differences (Asian vs Latin Americans), and age range (children vs adult) influenced the correlation and also contributed to the high level of heterogeneity in the studies. Our meta-analysis demonstrates that total-cholesterol and LDL-cholesterol levels should be explored as routine laboratory markers for dengue severity, as they will help in employing an appropriate patient therapy, and thus optimize the use of available resources. |
| Subject: | Dengue Colesterol Biomarcadores |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ALIMENTOS FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | 10.1002/rmv.2056 |
| URI: | http://hdl.handle.net/1843/41724 |
| Issue Date: | Sep-2019 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1002/rmv.2056 |
| metadata.dc.relation.ispartof: | Reviews in Medical Virology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.