Fator de crescimento derivado de plaquetas na implantodontia. Novas perspectivas de tratamento para reconstrução óssea

Abstract

The platelet-derived growth factor is a biological mediator that interferes with many cellular and molecular events that are important in the process of tissue regeneration, such as cell proliferation, chemotaxis and extracellular matrix synthesis. Several “in vitro” and “in vivo” have shown that these peptides can improve development and healing tissues, as only the bone tissue. The aim of this study was to conduct a review of the literature, to determine the effect of the use of growth factor plateletderived recombinant human (rh-PDGF-BB) on bone regeneration. Studies in cell cultures, animals and humans have shown that PDGF- BB alone, combined with other growth factors or different biomaterials, can improve the process of tissue regeneration. Thus, it seems that rhPDGF-BB (human recombinant) might be a new and important model of reconstructive therapy whenever the goal is the bone regeneration.