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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41837
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dc.creatorMarcelo Fernandes Ciprestept_BR
dc.creatorWagner da Nova Musselpt_BR
dc.creatorJuliana Batista da Silvapt_BR
dc.creatorMaria Betânia de Freitas Marquespt_BR
dc.creatorRonaldo Junio Campos Batistapt_BR
dc.creatorPedro Lana Gasteloispt_BR
dc.creatorWaldemar Augusto de Almeida Macedopt_BR
dc.creatorEdésia Martins Barros de Sousapt_BR
dc.date.accessioned2022-05-19T20:21:24Z-
dc.date.available2022-05-19T20:21:24Z-
dc.date.issued2020-11-01-
dc.citation.volume254pt_BR
dc.citation.spage1pt_BR
dc.citation.epage17pt_BR
dc.identifier.doi10.1016/j.matchemphys.2020.123265pt_BR
dc.identifier.issn0254-0584pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41837-
dc.description.resumoHydroxyapatite nanoparticles have been investigated as biological agents for the treatment and diagnosis of bone diseases due to their properties, providing high affinity to bone tissues and also due to the possibility to chemically modify the surfaces of these nanoparticles to provide active targeting to bone tumors or other bone disorders. In this work, synthetic hydroxyapatite nanoparticles and their surface modifications with folic and medronic acid were studied. Copper-64 was produced by neutron irradiation in a TRIGA MARK I nuclear reactor, and the functionalized nanoparticles radiolabeled with this radioisotope. The multi-technique characterization includes FTIR, PXRD, TGA, DSC, CHN, Zeta potential, XPS, SEM, TEM, and Gamma spectroscopy. Furthermore, the evaluation of the chemical interaction stability was through leaching tested for efficiency. The results indicate that folic and medronic acids can be covalently bonded to HA surface, producing a new material not yet described in the literature, been stably attached to hydroxyapatite nanoparticle surfaces, able to provide active targeting for bone disorders. The complexation of copper-64 provides high radiochemistry purity, although the specific activity must be improved.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMaterials Chemistry and Physicspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectTheranostic systempt_BR
dc.subjectHydroxyapatite nanoparticlespt_BR
dc.subjectCopper-64pt_BR
dc.subjectMDPpt_BR
dc.subjectFolatept_BR
dc.subjectMedronatept_BR
dc.subject.otherNanopartículas sintéticas de hidroxiapatitapt_BR
dc.subject.otherCobre-64pt_BR
dc.titleA new theranostic system for bone disorders: functionalized folate-MDP hydroxyapatite nanoparticles with radiolabeled copper-64pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0254058420306350pt_BR
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