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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41840
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dc.creatorWilliam Gustavo de Limapt_BR
dc.creatorRafaela Miranda Pessoapt_BR
dc.creatorKatia Duarte Vitalpt_BR
dc.creatorIsabella Kuniko Tavares Magalhaes Takenakapt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.date.accessioned2022-05-19T23:24:32Z-
dc.date.available2022-05-19T23:24:32Z-
dc.date.issued2020-
dc.citation.volume11pt_BR
dc.citation.issue4pt_BR
dc.citation.spage305pt_BR
dc.citation.epage318pt_BR
dc.identifier.doi10.3920/bm2019.0142pt_BR
dc.identifier.issn1876-2883pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41840-
dc.description.resumoGastrointestinal mucositis (GIM) is an inflammation caused by antitumor therapy, especially after chemotherapy and radiotherapy. Currently in the clinical practice, only palliative measures are taken to treat GIM, representing the main clinical limitation in the management of this condition. Several studies have highlighted the potential benefits of probiotics for the management of GIM, but the actual role of these microorganisms in the maintenance of intestinal homeostasis remains elusive. In this context, here we aimed to realise a systematic review with meta-analysis to evaluate the effect of probiotics on experimental GIM. The meta-analysis showed that probiotics significantly suppressed the body weight loss related to GIM in rodents (95% confidence interval (CI): -2.67 to -0.70; I2=98%, P<0.00). Subgroup analysis showed that pre-treatment (≥7 days before chemotherapy) (95% CI: -8.84 to -0.17; I2=98%, P<0.04) with a high dose of probiotics (≥ 109 cfu/day) (95% CI: -2.58 to -0.28; I2=98%, P<0.00) comprising two or more microorganism species (95% CI: -6.49 to -0.28; I2=96%, P=0.03) remedied GIM more effectively. It was also revealed that fungi (specifically Saccharomyces boullardii) are more effective in remedying GIM than bacteria (P=0.03 vs P<0.00), and the mouse models are more receptive than rats to the enteroprotective effects of probiotics (95% CI: -4.76, -0.69; I2=97%, P=0.01). Qualitative analyses highlighted that probiotics suppress GIM through several mechanisms; they reduce the intestinal permeability, suppress the pro-inflammatory cytokine production while stimulating production and secretion of anti-inflammatory cytokines, inhibit the signalling pathways coupled to inflammation and apoptosis, accelerate the proliferation of enterocytes, reduce the levels of reactive oxygen species, and help maintain the protective mucus layer. In conclusion, this review highlights the therapeutic benefits of probiotics in experimental GIM.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBeneficial Microbespt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBifidobacterium spp.pt_BR
dc.subjectLactobacillus spp.pt_BR
dc.subjectSaccharomyces spp.pt_BR
dc.subjectGastrointestinal mucositispt_BR
dc.subjectIntestinal microbiotapt_BR
dc.subject.otherBifidobacteriumpt_BR
dc.subject.otherLactobacilospt_BR
dc.subject.otherMucosite gastrointestinalpt_BR
dc.titleEffect of probiotics on the maintenance of intestinal homeostasis after chemotherapy: systematic review and meta-analysis of pre-clinical studiespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.wageningenacademic.com/doi/10.3920/BM2019.0142pt_BR
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