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http://hdl.handle.net/1843/41863
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DC Field | Value | Language |
---|---|---|
dc.creator | Carolina Mirtes Melo | pt_BR |
dc.creator | Jéssica Ferreira Cardoso | pt_BR |
dc.creator | Fernanda Barçante Perassoli | pt_BR |
dc.creator | Ari Soares de Oliveira Neto | pt_BR |
dc.creator | Luccas Moreira Pinto | pt_BR |
dc.creator | Maria Betânia de Freitas Marques | pt_BR |
dc.creator | Wagner da Nova Mussel | pt_BR |
dc.creator | Juliana Teixeira Magalhães | pt_BR |
dc.creator | Sandra Aparecida de Lima Moura | pt_BR |
dc.creator | Marcelo Gonzaga de Freitas Araújo | pt_BR |
dc.creator | Gisele Rodrigues da Silva | pt_BR |
dc.date.accessioned | 2022-05-20T20:08:29Z | - |
dc.date.available | 2022-05-20T20:08:29Z | - |
dc.date.issued | 2020-02-15 | - |
dc.citation.volume | 230 | pt_BR |
dc.citation.spage | 1 | pt_BR |
dc.citation.epage | 12 | pt_BR |
dc.identifier.doi | 10.1016/j.carbpol.2019.115608 | pt_BR |
dc.identifier.issn | 0144-8617 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/41863 | - |
dc.description.resumo | The treatment of vulvovaginal candidiasis (VVC) is based on oral and vaginal formulations which show limited effectiveness. In this study, amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid (AMP EUD nanoparticles/HA) were developed to overcome the drawbacks of the conventional formulations. AMP EUD nanoparticles/HA were synthesized by nanoprecipitation, formulated by statistical experimental design, and characterized. AMP release from EUD nanoparticles/HA and its antifungal activity in a murine model of VVC were evaluated. Nanoparticles showed 147.6 ± 16.7 nm of diameter, 0.301 ± 0.09 of polydispersity index, - 29.9 ± 3.76 mV of zeta potential, and 87.27 % of encapsulation efficiency. They released about 81 % of AMP in 96 h; and provided the elimination of 100 % of the vaginal fungal burden in 24 h. It was suggested that the AMP EUD nanoparticles/HA penetrated into the vaginal epithelium via CD44 receptors. These AMP EUD nanoparticles/HA represent a non-conventional vaginal formulation to improve the treatment of VVC. | pt_BR |
dc.description.sponsorship | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico | pt_BR |
dc.description.sponsorship | FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais | pt_BR |
dc.description.sponsorship | CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior | pt_BR |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | FAR - DEPARTAMENTO DE ALIMENTOS | pt_BR |
dc.publisher.department | ICX - DEPARTAMENTO DE QUÍMICA | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.relation.ispartof | Carbohydrate Polymers | pt_BR |
dc.rights | Acesso Restrito | pt_BR |
dc.subject | Eudragit RL100 | pt_BR |
dc.subject | Amphotericin B | pt_BR |
dc.subject | Hyaluronic acid | pt_BR |
dc.subject | Amphotericin B-loaded eudragit RL100 nanoparticles coated with hyaluronic acid | pt_BR |
dc.subject | Vulvovaginal candidiasis | pt_BR |
dc.subject.other | Candidíase vulvovaginal | pt_BR |
dc.subject.other | Ácido hialurônico | pt_BR |
dc.subject.other | Anfotericina B | pt_BR |
dc.subject.other | Nanopartículas Eudragit RL100 | pt_BR |
dc.title | Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.url.externa | https://www.sciencedirect.com/science/article/pii/S0144861719312767#! | pt_BR |
Appears in Collections: | Artigo de Periódico |
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