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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41863
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dc.creatorCarolina Mirtes Melopt_BR
dc.creatorJéssica Ferreira Cardosopt_BR
dc.creatorFernanda Barçante Perassolipt_BR
dc.creatorAri Soares de Oliveira Netopt_BR
dc.creatorLuccas Moreira Pintopt_BR
dc.creatorMaria Betânia de Freitas Marquespt_BR
dc.creatorWagner da Nova Musselpt_BR
dc.creatorJuliana Teixeira Magalhãespt_BR
dc.creatorSandra Aparecida de Lima Mourapt_BR
dc.creatorMarcelo Gonzaga de Freitas Araújopt_BR
dc.creatorGisele Rodrigues da Silvapt_BR
dc.date.accessioned2022-05-20T20:08:29Z-
dc.date.available2022-05-20T20:08:29Z-
dc.date.issued2020-02-15-
dc.citation.volume230pt_BR
dc.citation.spage1pt_BR
dc.citation.epage12pt_BR
dc.identifier.doi10.1016/j.carbpol.2019.115608pt_BR
dc.identifier.issn0144-8617pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41863-
dc.description.resumoThe treatment of vulvovaginal candidiasis (VVC) is based on oral and vaginal formulations which show limited effectiveness. In this study, amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid (AMP EUD nanoparticles/HA) were developed to overcome the drawbacks of the conventional formulations. AMP EUD nanoparticles/HA were synthesized by nanoprecipitation, formulated by statistical experimental design, and characterized. AMP release from EUD nanoparticles/HA and its antifungal activity in a murine model of VVC were evaluated. Nanoparticles showed 147.6 ± 16.7 nm of diameter, 0.301 ± 0.09 of polydispersity index, - 29.9 ± 3.76 mV of zeta potential, and 87.27 % of encapsulation efficiency. They released about 81 % of AMP in 96 h; and provided the elimination of 100 % of the vaginal fungal burden in 24 h. It was suggested that the AMP EUD nanoparticles/HA penetrated into the vaginal epithelium via CD44 receptors. These AMP EUD nanoparticles/HA represent a non-conventional vaginal formulation to improve the treatment of VVC.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCarbohydrate Polymerspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectEudragit RL100pt_BR
dc.subjectAmphotericin Bpt_BR
dc.subjectHyaluronic acidpt_BR
dc.subjectAmphotericin B-loaded eudragit RL100 nanoparticles coated with hyaluronic acidpt_BR
dc.subjectVulvovaginal candidiasispt_BR
dc.subject.otherCandidíase vulvovaginalpt_BR
dc.subject.otherÁcido hialurônicopt_BR
dc.subject.otherAnfotericina Bpt_BR
dc.subject.otherNanopartículas Eudragit RL100pt_BR
dc.titleAmphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0144861719312767#!pt_BR
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