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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41870
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dc.creatorMaria Aparecida Vieira Teixeira Garciapt_BR
dc.creatorCleverson Fernando Garciapt_BR
dc.creatorAndré Augusto Gomes Faracopt_BR
dc.date.accessioned2022-05-20T22:28:38Z-
dc.date.available2022-05-20T22:28:38Z-
dc.date.issued2020-07-
dc.citation.volume72pt_BR
dc.citation.issue7 - 8pt_BR
dc.citation.spage1pt_BR
dc.citation.epage15pt_BR
dc.identifier.doi10.1002/star.201900270pt_BR
dc.identifier.issn1521-379Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41870-
dc.description.resumoStarch is a natural, renewable, and biodegradable polymer produced by many plants as a source of stored energy. The structural and functional diversity of starches makes them suitable for different applications. Various physical, chemical, and enzymatic modifications can change and improve functional properties of starch to facilitate its use for different pharmaceutical purposes. Currently, some types of starches—for example, native starch, sodium starch glycolate (chemically modified starch), and pregelatinized starch (physically modified starch)—are approved by the United States Food and Drug Administration (FDA) for use either as an isolated excipient or as a matrix for drug delivery systems in granules, capsules, tablets, suppositories, implants, stents, transdermal, and ophthalmic systems. However, the increasing number of drug moieties with varying physicochemical and stability properties along with the development of new drug production processes and drug delivery systems exert pressure on formulators to search for new excipients that achieve the desired set of functionalities. This paper offers a clear overview of native and modified starches and their use in pharmaceutical and biomedical applications, either as excipients or as drug delivery systems. In addition, some drug release mechanisms, which include encapsulants, micro/nanoparticles hydrogels and scaffolds, are discussed.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofStarch - Stärkept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectDrug deliverypt_BR
dc.subjectExcipientspt_BR
dc.subjectStarch applicationspt_BR
dc.subjectStarch modificationspt_BR
dc.subject.otherAmidopt_BR
dc.subject.otherAmido nativopt_BR
dc.subject.otherAmido modificadopt_BR
dc.subject.otherAplicações farmacêuticaspt_BR
dc.subject.otherAplicações biomédicaspt_BR
dc.titlePharmaceutical and biomedical applications of native and modified starch: a reviewpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/star.201900270pt_BR
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