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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/41902
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dc.creatorJéssica Ferreira Cardosopt_BR
dc.creatorFernanda Barçante Perasolipt_BR
dc.creatorTamires Cunha Almeidapt_BR
dc.creatorMaria Betânia de Freitas Marquespt_BR
dc.creatorCibele Rodrigues Toledopt_BR
dc.creatorPriscilla Oliveira Gilpt_BR
dc.creatorHarley da Silva Tavarespt_BR
dc.creatorMariana Campos da Pazpt_BR
dc.creatorWagner da Nova Musselpt_BR
dc.creatorJuliana Teixeira Magalhãespt_BR
dc.creatorGlenda Nicioli da Silvapt_BR
dc.creatorArmando da Silva-Cunhapt_BR
dc.creatorPaulo Afonso Granjeiropt_BR
dc.creatorAlexander M. Klibanovpt_BR
dc.creatorGisele Rodrigues da Silvapt_BR
dc.date.accessioned2022-05-23T20:24:49Z-
dc.date.available2022-05-23T20:24:49Z-
dc.date.issued2021-02-01-
dc.citation.volume169pt_BR
dc.citation.spage330pt_BR
dc.citation.epage341pt_BR
dc.identifier.doi10.1016/j.ijbiomac.2020.12.057pt_BR
dc.identifier.issn0141-8130pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/41902-
dc.description.resumoVancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid (VCM-DMPEI nanoparticles/HA) were synthesized as an adjuvant for the treatment of bacterial endophthalmitis. The nanoparticles were formulated by experimental statistical design, thoroughly characterized, and evaluated in terms of bactericidal activity and both in vitro and in vivo ocular biocompatibility. The VCM-DMPEI nanoparticles/HA were 154 ± 3 nm in diameter with a 0.197 ± 0.020 polydispersity index; had a + 26.4 ± 3.3 mV zeta potential; exhibited a 93% VCM encapsulation efficiency; and released 58% of the encapsulated VCM over 96 h. VCM and DMPEI exhibited a synergistic bactericidal effect. The VCM-DMPEI nanoparticles/HA were neither toxic to ARPE-19 cells nor irritating to the chorioallantoic membrane. Moreover, the VCM-DMPEI nanoparticles/HA did not induce modifications in retinal functions, as determined by electroretinography, and in the morphology of the ocular tissues. In conclusion, the VCM-DMPEI nanoparticles/HA may be a useful therapeutic adjuvant to treat bacterial endophthalmitis.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Journal of Biological Macromoleculespt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectN,N-dodecyl, methyl-polyethylenimine (DMPEI)pt_BR
dc.subjectVancomycin-loaded coated nanoparticlespt_BR
dc.subjectHyaluronic acid (HA)pt_BR
dc.subject.otherEndoftalmite bacterianapt_BR
dc.subject.otherVancomicinapt_BR
dc.subject.otherÁcido hialurônicopt_BR
dc.titleVancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid to treat bacterial endophthalmitis: development, characterization, and ocular biocompatibilitypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0141813020352156#!pt_BR
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