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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/42474
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dc.creatorRafael Coelho Magalhaespt_BR
dc.creatorJanaina Matos Moreirapt_BR
dc.creatorAmanda Oliveira Lauarpt_BR
dc.creatorAriadna Andrade Saldanha da Silvapt_BR
dc.creatorAntônio Lúcio Teixeira Júniorpt_BR
dc.creatorAna Cristina Simões e Silvapt_BR
dc.date.accessioned2022-06-13T17:43:35Z-
dc.date.available2022-06-13T17:43:35Z-
dc.date.issued2019-12-
dc.citation.volume95pt_BR
dc.citation.spage1pt_BR
dc.citation.epage13pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ridd.2019.103508pt_BR
dc.identifier.issn0891-4222pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/42474-
dc.description.resumoBackground: An exacerbated systemic inflammatory response has been associated with the occurrence of central nervous system injuries that may determine, in long term, motor, sensorial and cognitive disabilities. Persistence of this exacerbated inflammatory response seems to be involved in the pathophysiology of cerebral palsy (CP). Methods: A systematic search was conducted in Bireme, Embase, PubMed and Scopus including studies that were published until August 2019. The key words used were “cerebral palsy”, “brain injury”, “inflammation”, “oxidative stress”, “cytokines”, “chemokines”, “neuropsychomotor development”, “neurodevelopment outcomes” and “child”. The quality of the eligible studies was determined according to the criteria suggested by the Newcastle-Ottawa Scale (NOS). Results: Fourteen eligible studies aimed to investigate the association between peripheral inflammatory molecules and neurodevelopment in infants. The studies differed regarding CP-related risk factors and its classification. Inflammatory proteins were measured in blood, plasma, serum, cerebrospinal fluid or urine. In ten studies, higher circulating levels of cytokines, including IL-1β, IL-6, TNF and CXCL8/IL-8, were associated with abnormal neurological findings. Conclusion: The investigation of the potential association between inflammatory molecules and neurological development in children with CP requires further original studies in order to clarify the influence of prenatal and perinatal inflammation on neurological outcomes.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE TERAPIA OCUPACIONALpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofResearch in Developmental Disabilitiespt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectCerebral palsypt_BR
dc.subjectInflammationpt_BR
dc.subjectOxidative stresspt_BR
dc.subjectCytokinespt_BR
dc.subjectNeurodevelopment outcomept_BR
dc.subject.otherParalisia cerebralpt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherEstresse oxidativopt_BR
dc.subject.otherCitocinaspt_BR
dc.subject.otherSistema nervoso central / lesõespt_BR
dc.titleInflammatory biomarkers in children with cerebral palsy: A systematic reviewpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0891422219301751?via%3Dihubpt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-8960-2256pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5369-9175pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-9621-5422pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-9222-3882pt_BR
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