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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/42554
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dc.creatorIsabelle Arruda Barbosapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorEloá Mangabeira Santospt_BR
dc.creatorAlanna Fernandes Paraísopt_BR
dc.creatorPablo Vinicyus Ferreira Chagaspt_BR
dc.creatorLuís Paulo Oliveirapt_BR
dc.creatorJoão Marcus Oliveira Andradept_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorBruna Mara Aparecida de Carvalho Mesquitapt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.date.accessioned2022-06-20T15:30:44Z-
dc.date.available2022-06-20T15:30:44Z-
dc.date.issued2019-
dc.citation.volume20pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.mgene.2019.100553pt_BR
dc.identifier.issn2214-5400pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/42554-
dc.description.resumoLiraglutide, an important pharmacological agent used to improve glycemic status and weight control, has emerged as a therapeutic strategy for hepatic steatosis treatment. Objective: The aim of the present study was to analyze the influence of liraglutide in hepatic steatosis and evaluate the potential target genes involved in the liraglutide action in the hepatic steatosis through a bioin-formatics study. Methods & procedures: We performed an animal study with male mice divided into three groups: standard, high-fat diet and the third group were fed a high-fat diet and treated with liraglutide at a dose of 0.6 mg/kg body weight. Blood parameters (glucose tolerance and insulin sensitivity tests, total cholesterol, high-density lipo-protein-C, triglycerides and glucose levels) were evaluated. mRNA analysis for ACC and FAS were performed.Gene databases, and bioinformatics algorithms were used to generate molecular targets for liraglutide and he-patic steatosis based on in silico investigation. Interactions networks between protein coding were accessed. Results: The present study showed that liraglutide decreased glucose levels, total cholesterol and triglycerides in obese animals as compared to the high-fat-fed obese mice. AKT and RPS6KB1 genes presented higher disease-related connectivity. Interaction Network exhibited a power law behavior in correlation: 0.896; R2: 0.796. Ontological analysis demonstrated different mechanisms associated such as regulation of signaling process. Conclusion: The present study reveals relevant information regarding the liraglutide effects in hepatic steatosis. The liraglutide improved hyperglycemia and attenuated hepatic steatosis in mice fed a high-fat diet.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMeta Genept_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherFígado gordurosopt_BR
dc.subject.otherSíndrome metabólicapt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherGenespt_BR
dc.titleLiraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S221454001930012Xpt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-8980-8599pt_BR
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