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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/42594
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Campo DCValorIdioma
dc.creatorJeanne Brenda Martinspt_BR
dc.creatorVanessa Amaral Mendonçapt_BR
dc.creatorGrazielle Cordeiro Aguiarpt_BR
dc.creatorSueli Ferreira da Fonsecapt_BR
dc.creatorJousielle Márcia dos Santospt_BR
dc.creatorRosalina Tossige Gomespt_BR
dc.creatorDirceu de Sousa Melopt_BR
dc.creatorMurilo Xavier Oliveirapt_BR
dc.creatorHércules Ribeiro Leitept_BR
dc.creatorAna Cristina Resende Camargospt_BR
dc.creatorAnderson José Ferreirapt_BR
dc.creatorCândido Celso Coimbrapt_BR
dc.creatorJacques Poortmanspt_BR
dc.creatorVinícius Cunha Oliveirapt_BR
dc.creatorSara Barros Silvapt_BR
dc.creatorTalita Emanuela Dominguespt_BR
dc.creatorMario Bernardo Filhopt_BR
dc.creatorAna Cristina Rodrigues Lacerdapt_BR
dc.date.accessioned2022-06-22T14:28:39Z-
dc.date.available2022-06-22T14:28:39Z-
dc.date.issued2019-09-
dc.citation.volume10pt_BR
dc.citation.issue1168pt_BR
dc.citation.spage1pt_BR
dc.citation.epage10pt_BR
dc.identifier.doihttps://doi.org/10.3389/fphys.2019.01168pt_BR
dc.identifier.issn1664-042Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/42594-
dc.description.resumoBackground: Knee osteoarthritis (kOA) is a common chronic disease that induces changes in redox status and inflammatory biomarkers, cell death, and motor impairment. Aerobic training can be a non-pharmacological alternative to prevent the progression of the disease. Objective: To evaluate the effects of an 8 weeks moderate-intensity treadmill aerobic training program on redox status and inflammatory biomarkers and motor performance in kOA-like changes induced by monosodium iodoacetate (MIA) in rats. Methods: Twenty-seven rats were randomly divided into three groups: SHAM; induced kOA (OA); and induced kOA + aerobic training (OAE). Motor performance was evaluated by the number of falls on rotarod test, the total time of displacement and the number of failures on a 100 cm footbridge. Data for cytokines and histology were investigated locally, whereas plasma was used for redox status biomarkers. Results: The OA group, compared to the SHAM group, increased 1.13 times the total time of displacement, 6.05 times the number of failures, 2.40 times the number of falls. There was also an increase in cytokine and in thiobarbituric acid reactive substances (TBARS) (IL1β: 5.55-fold, TNF: 2.84-fold, IL10: 1.27-fold, IL6: 1.50-fold, TBARS: 1.14-fold), and a reduction of 6.83% in the total antioxidant capacity (FRAP), and of 35% in the number of chondrocytes. The aerobic training improved the motor performance in all joint function tests matching to SHAM scores. Also, it reduced inflammatory biomarkers and TBARS level at values close to those of the SHAM group, with no change in FRAP level. The number of falls was explained by IL1β and TNF (58%), and the number of failures and the total time of displacement were also explained by TNF (29 and 21%, respectively). Conclusion: All findings indicate the efficacy of moderate-intensity aerobic training to regulate inflammatory biomarkers associated with improved motor performance in induced kOA-like changes, thus preventing the loss of chondrocytes.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Physiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectOsteoarthritispt_BR
dc.subjectAerobic trainingpt_BR
dc.subjectExercisept_BR
dc.subjectBiomarkerspt_BR
dc.subjectJoint functionpt_BR
dc.subject.otherOsteoartritept_BR
dc.subject.otherExercícios aeróbicospt_BR
dc.subject.otherBiomarcadorespt_BR
dc.subject.otherArticulações - Aspectos fisiológicospt_BR
dc.subject.otherRatospt_BR
dc.titleEffect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/fphys.2019.01168/fullpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1696-6091pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0003-0420-445Xpt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-6358-4910pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0001-8977-8131pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-2719-4231pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0001-8981-6724pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-8658-3774pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-4718-448Xpt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-5366-3754pt_BR
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