1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/42631
Full metadata record
DC FieldValueLanguage
dc.creatorPhilipp Schuetzpt_BR
dc.creatorJean Chastrept_BR
dc.creatorFlorence Tubachpt_BR
dc.creatorKristina Kristoffersenpt_BR
dc.creatorOlaf Burkhardtpt_BR
dc.creatorTobias Weltept_BR
dc.creatorStefan Schroederpt_BR
dc.creatorVandack Nobrept_BR
dc.creatorLong Weipt_BR
dc.creatorHeiner Bucherpt_BR
dc.creatorNeera Bhatnagarpt_BR
dc.creatorYannick Wirzpt_BR
dc.creatorDjillali Annanept_BR
dc.creatorKonrad Reinhartpt_BR
dc.creatorAngela Branchept_BR
dc.creatorPierre Damaspt_BR
dc.creatorMaarten Nijstenpt_BR
dc.creatorDylan de Langept_BR
dc.creatorRodrigo o Deliberatopt_BR
dc.creatorStella Limapt_BR
dc.creatorVera Maravi'-stojkovi'pt_BR
dc.creatorAlessia Verduript_BR
dc.creatorRamon Sagerpt_BR
dc.creatorBin Caopt_BR
dc.creatorYahya Shehabipt_BR
dc.creatorAlbertus Beishuizenpt_BR
dc.creatorJens-ulrik Jensenpt_BR
dc.creatorCaspar Cortipt_BR
dc.creatorJos a Van Oerspt_BR
dc.creatorAnn Falseypt_BR
dc.creatorEvelien de Jongpt_BR
dc.creatorCarolina Ferreira de Oliveirapt_BR
dc.creatorBianca Beghept_BR
dc.creatorMirjam Christ-crainpt_BR
dc.creatorMatthias Brielpt_BR
dc.creatorBeat Muellerpt_BR
dc.creatorDaiana Stolzpt_BR
dc.creatorMichael Tammpt_BR
dc.creatorLila Bouadmapt_BR
dc.creatorCharles e Luytpt_BR
dc.creatorMichel Wolffpt_BR
dc.date.accessioned2022-06-23T21:46:16Z-
dc.date.available2022-06-23T21:46:16Z-
dc.date.issued2017-
dc.citation.volume1pt_BR
dc.identifier.doi10.1002/14651858.cd007498.pub3pt_BR
dc.identifier.issn1465-1858pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/42631-
dc.description.resumoBackground Acute respiratory infections (ARIs) comprise of a large and heterogeneous group of infections including bacterial, viral, and other aetiologies. In recent years, procalcitonin (PCT), a blood marker for bacterial infections, has emerged as a promising tool to improve decisions about antibiotic therapy (PCT‐guided antibiotic therapy). Several randomised controlled trials (RCTs) have demonstrated the feasibility of using procalcitonin for starting and stopping antibiotics in different patient populations with ARIs and different settings ranging from primary care settings to emergency departments, hospital wards, and intensive care units. However, the effect of using procalcitonin on clinical outcomes is unclear. This is an update of a Cochrane review and individual participant data meta‐analysis first published in 2012 designed to look at the safety of PCT‐guided antibiotic stewardship. Objectives The aim of this systematic review based on individual participant data was to assess the safety and efficacy of using procalcitonin for starting or stopping antibiotics over a large range of patients with varying severity of ARIs and from different clinical settings. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), which contains the Cochrane Acute Respiratory Infections Group's Specialised Register, MEDLINE, and Embase, in February 2017, to identify suitable trials. We also searched ClinicalTrials.gov to identify ongoing trials in April 2017. Selection criteria We included RCTs of adult participants with ARIs who received an antibiotic treatment either based on a procalcitonin algorithm (PCT‐guided antibiotic stewardship algorithm) or usual care. We excluded trials if they focused exclusively on children or used procalcitonin for a purpose other than to guide initiation and duration of antibiotic treatment. Data collection and analysis Two teams of review authors independently evaluated the methodology and extracted data from primary studies. The primary endpoints were all‐cause mortality and treatment failure at 30 days, for which definitions were harmonised among trials. Secondary endpoints were antibiotic use, antibiotic‐related side effects, and length of hospital stay. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable hierarchical logistic regression adjusted for age, gender, and clinical diagnosis using a fixed‐effect model. The different trials were added as random‐effects into the model. We conducted sensitivity analyses stratified by clinical setting and type of ARI. We also performed an aggregate data meta‐analysis. Main results From 32 eligible RCTs including 18 new trials for this 2017 update, we obtained individual participant data from 26 trials including 6708 participants, which we included in the main individual participant data meta‐analysis. We did not obtain individual participant data for four trials, and two trials did not include people with confirmed ARIs. According to GRADE, the quality of the evidence was high for the outcomes mortality and antibiotic exposure, and quality was moderate for the outcomes treatment failure and antibiotic‐related side effects. Primary endpoints: there were 286 deaths in 3336 procalcitonin‐guided participants (8.6%) compared to 336 in 3372 controls (10.0%), resulting in a significantly lower mortality associated with procalcitonin‐guided therapy (adjusted OR 0.83, 95% CI 0.70 to 0.99, P = 0.037). We could not estimate mortality in primary care trials because only one death was reported in a control group participant. Treatment failure was not significantly lower in procalcitonin‐guided participants (23.0% versus 24.9% in the control group, adjusted OR 0.90, 95% CI 0.80 to 1.01, P = 0.068). Results were similar among subgroups by clinical setting and type of respiratory infection, with no evidence for effect modification (P for interaction > 0.05). Secondary endpoints: procalcitonin guidance was associated with a 2.4‐day reduction in antibiotic exposure (5.7 versus 8.1 days, 95% CI ‐2.71 to ‐2.15, P < 0.001) and lower risk of antibiotic‐related side effects (16.3% versus 22.1%, adjusted OR 0.68, 95% CI 0.57 to 0.82, P < 0.001). Length of hospital stay and intensive care unit stay were similar in both groups. A sensitivity aggregate‐data analysis based on all 32 eligible trials showed similar results. Authors' conclusions This updated meta‐analysis of individual participant data from 12 countries shows that the use of procalcitonin to guide initiation and duration of antibiotic treatment results in lower risks of mortality, lower antibiotic consumption, and lower risk for antibiotic‐related side effects. Results were similar for different clinical settings and types of ARIs, thus supporting the use of procalcitonin in the context of antibiotic stewardship in people with ARIs. Future high‐quality research is needed to confirm the results in immunosuppressed patients and patients with non‐respiratory infections.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCochrane librarypt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherProcalcitoninapt_BR
dc.subject.otherAntibióticospt_BR
dc.subject.otherInfecçõespt_BR
dc.subject.otherTrato respiratóriopt_BR
dc.titleProcalcitonin to initiate or discontinue antibiotics in acute respiratory tract infectionspt_BR
dc.title.alternativeProcalcitonina para iniciar ou descontinuar antibióticos em infecções agudas do trato respiratóriopt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD007498.pub3/fullpt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
2017_Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections.pdf1.04 MBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.