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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/43307
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dc.creatorStephanie Mathiesonpt_BR
dc.creatorRichard Kaschpt_BR
dc.creatorChristopher Maherpt_BR
dc.creatorRafael Zambelli de Almeida Pintopt_BR
dc.creatorAndrew McLachlanpt_BR
dc.creatorBart Koespt_BR
dc.creatorChung-Wei Christine Linpt_BR
dc.date.accessioned2022-07-15T13:41:08Z-
dc.date.available2022-07-15T13:41:08Z-
dc.date.issued2019-01-
dc.citation.volume20pt_BR
dc.citation.issue1pt_BR
dc.citation.spage1pt_BR
dc.citation.epage15pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jpain.2018.06.005pt_BR
dc.identifier.issn1526-5900pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/43307-
dc.description.resumoCombining medicines may give greater pain relief and/or improved tolerability. We conducted a systematic review to investigate the effects of combination drug therapy in patients with low back pain and/or sciatica on pain, disability, and adverse events. Databases and trial registers were searched from inception to July 27, 2017, for randomized trials of (sub)acute or chronic back pain or sciatica participants that were administered combination drug therapy compared with monotherapy or placebo. Of the 27 studies included, most combinations (21 of 23) consisted of single trials. Most combinations had no or small effect on pain and disability. A clinically important difference was found in one combination, buprenorphine plus pregabalin versus buprenorphine for chronic back pain at immediate (mean difference = –23.30; 95% confidence interval = –27.68 to –18.92) and short (mean difference = –27.60; 95% confidence interval = –31.70 to –23.50) terms; however, the quality of evidence was low. There was no statistically significant increased risk of serious adverse events. When the risk of adverse events was statistically significant, it favored monotherapy or placebo. There is no clear evidence to support any combination drug therapy for the management of low back pain and sciatica due to the limited number of studies and overall low quality of evidence. Perspective: Combining medicines may give greater pain relief and/or improved tolerability compared with single-ingredient medicines. However, the lack of studies and overall low quality of evidence limit the recommendation of combination drug therapy for the management of low back pain and sciatica.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Painpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBack painpt_BR
dc.subjectAnalgesicspt_BR
dc.subjectsciaticapt_BR
dc.subjectsystematic reviewpt_BR
dc.subjectmedicinept_BR
dc.subject.otherDor nas costaspt_BR
dc.subject.otherAnalgésicospt_BR
dc.subject.otherCiáticapt_BR
dc.subject.otherRevisão sistemáticapt_BR
dc.subject.otherMedicamentospt_BR
dc.titleCombination drug therapy for the management of low back pain and sciatica: systematic review and meta-analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1526590018303195?via%3Dihub#!pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-7335-8842pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-1628-7857pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2775-860Xpt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0003-4674-0242pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-0450-9969pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-6192-7238pt_BR
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