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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/43829
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dc.creatorPatrícia da Conceição Rocha Rabelopt_BR
dc.creatorLetícia Maria de Souza Cordeiropt_BR
dc.creatorNayara Soares Sena Aquinopt_BR
dc.creatorBruno Bernardo Barbosa Fonsecapt_BR
dc.creatorCândido Celso Coimbrapt_BR
dc.creatorSamuel Penna Wannerpt_BR
dc.creatorRaphael Escorsim Szawkapt_BR
dc.creatorDanusa Dias Soarespt_BR
dc.date.accessioned2022-08-01T12:27:18Z-
dc.date.available2022-08-01T12:27:18Z-
dc.date.issued2019-
dc.citation.volume126pt_BR
dc.citation.issue2pt_BR
dc.citation.spage393pt_BR
dc.citation.epage402pt_BR
dc.identifier.doihttps://doi.org/10.1152/japplphysiol.00092.2018pt_BR
dc.identifier.issn1522-1601pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/43829-
dc.description.resumoThe present study investigated whether intrinsic exercise capacity affects the changes in thermoregulation, metabolism and central dopamine (DA) induced by treadmill running. Male Wistar rats were subjected to three incremental exercises and ranked as low-performance (LP), standard-performance (SP), and high-performance (HP) rats. In the first experiment, abdominal (TABD) and tail (TTAIL) temperatures were registered in these rats during submaximal exercise (SE) at 60% of maximal speed. Immediately after SE, rats were decapitated and concentrations of DA and 3,4-dihydroxyphenylacetic acid (DOPAC) were determined in the preoptic area (POA). In the second experiment, oxygen consumption was measured and mechanical efficiency (ME) was calculated in these rats during an incremental exercise. HP rats ran for longer periods and were fatigued with higher TABD values, with no difference in TTAIL. Nevertheless, thermoregulatory efficiency was higher in HP rats, compared with other groups. DA and DOPAC concentrations in the POA were increased by SE, with higher levels in HP compared with LP and SP rats. V̇o2 also differed between groups, with HP rats displaying a lower consumption throughout the incremental exercise but a higher V̇o2 at fatigue. ME, in turn, was consistently higher in HP than in LP and SP rats. Thus, our results show that HP rats have greater TABD values at fatigue, which seem to be related to a higher dopaminergic activity in the POA. Moreover, HP rats exhibited a greater thermoregulatory efficiency during exercise, which can be attributed to a lower V̇o2, but not to changes in tail heat loss mechanisms. NEW & NOTEWORTHY: Our findings reveal that rats with higher intrinsic exercise capacities have greater thermoregulatory efficiencies and increased dopaminergic activity in the preoptic area, a key brain area in thermoregulatory control, while exercising. Moreover, higher intrinsic exercise capacities are associated with decreased oxygen consumption for a given exercise intensity, which indicates greater mechanical efficiencies. Collectively, these findings help to advance our knowledge of why some rats of a given strain can exercise for longer periods than others.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Applied Physiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectFatiguept_BR
dc.subjectMonoaminespt_BR
dc.subjectOxygen consumptionpt_BR
dc.subjectPerformancept_BR
dc.subjectTemperaturept_BR
dc.subject.otherFadigapt_BR
dc.subject.otherAminaspt_BR
dc.subject.otherConsumo de oxigêniopt_BR
dc.subject.otherDesempenhopt_BR
dc.subject.otherTemperaturapt_BR
dc.titleRats with higher intrinsic exercise capacities exhibit greater preoptic dopamine levels and greater mechanical and thermoregulatory efficiencies while runningpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.physiology.org/doi/full/10.1152/japplphysiol.00092.2018?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orgpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8981-6724pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-4659-1032pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2639-3469pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-5705-8890pt_BR
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