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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44178
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dc.creatorKeyla Laisa Araújo e Saldanhapt_BR
dc.creatorVanessa de Andrade Royopt_BR
dc.creatorFrancine Souza Alves da Fonsecapt_BR
dc.creatorElytania Veiga Menezespt_BR
dc.creatorDario Alves de Oliveirapt_BR
dc.creatorAfrânio Farias de Melo Júniorpt_BR
dc.creatorKamylla Santos Teixeirapt_BR
dc.creatorMurilo Malveira Brandãopt_BR
dc.creatorMarcel Nani Leitept_BR
dc.creatorGuilherme Ferreira Caetanopt_BR
dc.creatorMarco Andrey Cipriani Fradept_BR
dc.date.accessioned2022-08-11T11:01:17Z-
dc.date.available2022-08-11T11:01:17Z-
dc.date.issued2019-
dc.citation.volume11pt_BR
dc.citation.issue3pt_BR
dc.citation.spage193pt_BR
dc.citation.epage200pt_BR
dc.identifier.doi10.4103/pr.pr_30_19pt_BR
dc.identifier.issn0974-8490pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44178-
dc.description.resumoBackground: Hymenaea stigonocarpa Mart. (Fabaceae ) is one of the plant species commonly found in Brazilian cerrado. It is popularly known as jatobá-do-cerrado. Phytochemical studies of different parts of the plant demonstrated the presence of sesquiterpenes, diterpenes, and oligosaccharides. The species produces an opaque, translucent, pale yellow, or almost white resin rich in labdanóides compounds, widely used in folk medicine, but without proving its pharmacological actions. Objective: To analyze the H. stigonocarpa resin to confirm its pharmacological actions through specific tests for cicatrization, nociception, and cytotoxicity and to evaluate the chemical composition through the gas chromatography coupled to mass spectrometry (GC-MS). Materials and Methods: The cell proliferation/migration capacity was evaluated using the scratch assay method and the cell viability determined by the 3-[4,5-dimethylthiazol-2-yl]–tetrazolium 2,5-diphenyl-bromide cytotoxicity assay. In the pharmacological tests were performed Abdominal Contortions induced by acetic acid and Nociceptive Response evaluated by the Formalin Test. GC-MS was used to trace the profile of the bioactive compounds of the resin. Results: It was possible to verify the presence of terpene compounds with the labdanos skeleton. Structures that revealed important pharmacological actions regarding healing, evidenced by the scratch assay test and nociceptive activity demonstrated by the animal tests. No cytotoxic activity was detected at the dosages tested. Conclusion: The results obtained confirm the pharmacological action of the species and can be used to elaborate on new therapies, which will increase the therapeutic arsenal available to the population.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPharmacognosy Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherPlantas dos cerradospt_BR
dc.subject.otherFarmacologiapt_BR
dc.subject.otherAnálise cromatográficapt_BR
dc.subject.otherEspectroscopia de massapt_BR
dc.subject.otherQuímica vegetalpt_BR
dc.subject.otherDiterpenospt_BR
dc.subject.otherTerpenospt_BR
dc.subject.otherSesquiterpenospt_BR
dc.subject.otherOligossacarídeospt_BR
dc.titleCytotoxic action and proliferation in vitro and analgesic activity in vivo of resin from Hymenaea stigonocarpapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.phcogres.com/article/2019/11/3/104103prpr3019pt_BR
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