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http://hdl.handle.net/1843/44215| Type: | Artigo de Periódico |
| Title: | Effects of omentectomy in addition to sleeve gastrectomy on the metabolic and inflammatory profiles of obese rats |
| Authors: | Thaísa Soares Crespo João Marcus Oliveira Andrade Antônio Sérgio Barcala Jorge Alfredo Maurício Batista de Paula André Luís Sena Guimarães Sérgio Henrique Sousa Santos |
| Abstract: | Background: visceral obesity has been considered a risk factor for metabolic and cardiovascular complications. In an attempt to reduce the visceral adipose tissue, omentectomy has been proposed to be performed along with bariatric surgery. Objective: the goal of this study was to evaluate whether omentectomy associated with sleeve gastrectomy (SG) is beneficial to the inflammatory and metabolic profile of rats fed a standard diet (STD) or high-fat diet (HFD). Setting: University hospital, Brazil. Methods: for this experiment, male Wistar rats were randomly divided into 6 groups as follows: sham surgery (STD+L or HFD+L), SG alone (STD+SG or HFD+SG), or SG with omentectomy (STD+SGO or HFD+SGO). Anthropometric data and metabolic profiles were evaluated, and the tissue expression of inflammatory markers in the visceral adipose tissue was measured. Results: in rats with diet-induced obesity treated with SG with or without omentectomy, there was a reduction in weight (HFD+SG: P<.01 and HFD+SGO: P<.05), adiposity (HFD+SG: P<.001 and HFD+SGO: P<.05), plasma levels of glucose (HFD+SG: P<.01 and HFD+SGO: P<.01), plasma levels of C-peptide (HFD+SG: P<.01 and HFD+SGO: P<.001), plasma levels of insulin (HFD+SG: P<.05 and HFD+SGO: P<.001), plasma levels of total cholesterol (HFD+SG: P<.01 and HFD+SGO: P<.01), and tissue expression of TNF-α (HFD+SG: P<.001 and HFD+SGO: P<.01), but there was no statistically significant difference between the groups in which omentectomy was performed or was not. Conclusion: in this study, we did not observe additional beneficial effects due to omentectomy associated with SG in the metabolic profile and tissue expression of inflammatory markers. |
| Subject: | Obesidade Gastrectomia Cirurgia bariátrica Emagrecimento Inflamação |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.soard.2016.01.026 |
| URI: | http://hdl.handle.net/1843/44215 |
| Issue Date: | Aug-2016 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S1550728916000319?via%3Dihub |
| metadata.dc.relation.ispartof: | Surgery for Obesity and Related Diseases |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Effects of omentectomy in addition to sleeve gastrectomy on the metabolic and inflammatory profiles of obese rats.pdf | 1.34 MB | Adobe PDF | View/Open |
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