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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44256
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dc.creatorLeandro Ceotto Freitas Limapt_BR
dc.creatorSoraya Wilke Salibapt_BR
dc.creatorJoão Marcus de Oliveira Andradept_BR
dc.creatorMaria Luísa Cunhapt_BR
dc.creatorPuebla Cassini-Vieirapt_BR
dc.creatorJohn David Feltenbergerpt_BR
dc.creatorLucíola da Silva Barcelospt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorAlfredo Mauricio Batista de Paulapt_BR
dc.creatorAntônio Carlos Pinheiro de Oliveirapt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.date.accessioned2022-08-15T13:12:23Z-
dc.date.available2022-08-15T13:12:23Z-
dc.date.issued2016-05-16-
dc.citation.volume54pt_BR
dc.citation.spage3465pt_BR
dc.citation.epage3475pt_BR
dc.identifier.doi10.1007/s12035-016-9927-xpt_BR
dc.identifier.issn1559-1182pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44256-
dc.description.resumoDifferent factors may contribute to the development of neurodegenerative diseases. Among them, metabolic syndrome (MS), which has reached epidemic proportions, has emerged as a potential element that may be involved in neurodegeneration. Furthermore, studies have shown the importance of the sirtuin family in neuronal survival and MS, which opens the possibility of new pharmacological targets. This study investigates the influence of sirtuin metabolic pathways by examining the functional capacities of glucose-induced obesity in an excitotoxic state induced by a quinolinic acid (QA) animal model. Mice were divided into two groups that received different diets for 8 weeks: one group received a regular diet, and the other group received a high-fat diet (HF) to induce MS. The animals were submitted to a stereotaxic surgery and subdivided into four groups: Standard (ST), Standard-QA (ST-QA), HF and HF-QA. The QA groups were given a 250 nL quinolinic acid injection in the right striatum and PBS was injected in the other groups. Obese mice presented with a weight gain of 40 % more than the ST group beyond acquiring an insulin resistance. QA induced motor impairment and neurodegeneration in both ST-QA and HF-QA, although no difference was observed between these groups. The HF-QA group showed a reduction in adiposity when compared with the groups that received PBS. Therefore, the HF-QA group demonstrated a commitment-dependent metabolic pathway. The results suggest that an obesogenic diet does not aggravate the neurodegeneration induced by QA. However, the excitotoxicity induced by QA promotes a sirtuin pathway impairment that contributes to metabolic changes.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMolecular Neurobiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherDegeneração (Patologia)pt_BR
dc.subject.otherSíndrome metabólicapt_BR
dc.subject.otherObesidadept_BR
dc.titleNeurodegeneration alters metabolic profile and Sirt 1 signaling in high-fat-induced obese micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s12035-016-9927-xpt_BR
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