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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44301
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dc.creatorEliane Macedo Sobrinho Santospt_BR
dc.creatorTalita Antunes Guimarãespt_BR
dc.creatorHércules Otacílio Santospt_BR
dc.creatorSueli Nunes Fonsecapt_BR
dc.creatorTalita Antunes Guimarãespt_BR
dc.creatorCarlos Alberto de Carvalho Fragapt_BR
dc.creatorKimberly Marie Jonespt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.date.accessioned2022-08-17T12:45:20Z-
dc.date.available2022-08-17T12:45:20Z-
dc.date.issued2016-05-01-
dc.citation.volume5pt_BR
dc.citation.issue1pt_BR
dc.identifier.doi10.4172/2329-9533.1000124pt_BR
dc.identifier.issn2329-9533pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44301-
dc.description.resumoIt is important to understand the biological processes linking obesity and cancer to identify new molecular targets for development of better therapeutic strategies. This study aims to synthesize knowledge regarding possible associations between obesity-related genes and oral cancer. We performed literature review about “oral cancer” and “obesity”. Gene databases and bioinformatics algorithms were used to in silico investigation of interactions networks between proteincoding genes, leader genes and molecular pathways that can possibly to link both pathological mechanisms. To this, GeneCards database, softwares STRING, Metaboanalyst and Cytoscape were employed. Genes were found to interact directly or indirectly with both obesity and oral cancer. Analyses of clustering revealed the TP53 gene as leader gene. Leptin was presented in group with the highest scores of relevance. Protein-protein interaction network linking obesity and oral cancer exhibits a power law behavior (correlation: 0.907; R2:0.851). Analysis of linear regression shows that genes related to obesity and oral cancer have higher diseaserelated connectivity than a global connectivity. Onthological analysis demonstrated different mechanisms associated to obesity and oral cancer, such as regulation of apoptosis and positive regulation of cellular process. We hypothesized that leptin is a molecule key in the link between obesity and oral cancer, by interactions with the p53 protein through CREBBP and EP300 proteins and HIF-1α, promoting angiogenesis. This study sought to organize relevant informations to further illuminate the role of genes that may be related to obesity and oral cancer. Angiogenesis genes can to be suggested as important factors to link both pathological processes.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Applied Bioinformatics & Computational Biologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherBoca - Câncerpt_BR
dc.subject.otherNeovascularizaçãopt_BR
dc.subject.otherBioinformáticapt_BR
dc.subject.otherCélulas - Proliferaçãopt_BR
dc.subject.otherCarcinoma de células escamosaspt_BR
dc.titleObesity-related genes and oral cancer: a bioinformatics approach and systematic reviewpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scitechnol.com/peer-review/obesityrelated-genes-and-oral-cancer-a-bioinformatics-approach-and-systematicreview-K3Eo.php?article_id=4926pt_BR
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