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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44304
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dc.creatorAntônio Sérgio Barcala Jorgept_BR
dc.creatorJoão Marcus Oliveira Andradept_BR
dc.creatorAlanna Fernandes Paraísopt_BR
dc.creatorGislaine Cândida Batista Jorgept_BR
dc.creatorChristine Mendes Silveirapt_BR
dc.creatorLudmilla Regina de Souzapt_BR
dc.creatorErivelton Pereira Santospt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.creatorAlfredo Mauricio Batista de Paulapt_BR
dc.date.accessioned2022-08-17T13:06:48Z-
dc.date.available2022-08-17T13:06:48Z-
dc.date.issued2018-
dc.citation.volume12pt_BR
dc.citation.issue1pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.orcp.2016.03.009pt_BR
dc.identifier.issn1871-403Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44304-
dc.description.resumoObjectives: to analyze the mRNA expression of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) in the liver and white adipose tissue samples of individuals with class III obesity (body mass index ≥40.0 kg/m2) with non-alcoholic fatty liver disease (NAFLD). Methods: this cross-sectional study included patients with class III obesity exhibiting early or late morphological presentation of NAFLD (non-alcoholic hepatic steatosis [NAFL], n = 8 and non-alcoholic steatohepatitis [NASH], n = 13, respectively). All patients underwent bariatric surgery and peripheral blood, liver, and visceral white adipose tissue (WAT) samples were collected. Socio-demographic, anthropometric, clinical, plasma biochemical, and nutritional characteristics of each study subject were assessed and compared between patients presenting with NAFL and NASH. IL-6 and TNF-α mRNA expression in the liver and WAT samples were measured by using quantitative real time-polymerase chain reaction (qRT-PCR). Results: individuals with class III obesity and NASH showed higher body mass index (BMI) and higher IL-6 and TNF-α mRNA expression in the WAT compared to that of patients with NAFL (p = 0.01, for all associations). Conclusions: individuals with class III obesity with higher morphological severity of NAFLD exhibited higher BMI and higher IL-6 and TNF-α expression in the WAT. Future prospective studies are warranted to determine how BMI, IL-6, and TNF-α affect the progression of NAFLD in individuals with class III obesity.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofObesity Research & Clinical Practicept_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherÍndice de massa corporalpt_BR
dc.subject.otherTecido adiposopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherFígado - Doençaspt_BR
dc.subject.otherCitocinaspt_BR
dc.titleBody mass index and the visceral adipose tissue expression of IL-6 and TNF-alpha are associated with the morphological severity of non-alcoholic fatty liver disease in individuals with class III obesitypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1871403X16300060?via%3Dihubpt_BR
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