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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44341
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dc.creatorAntônio Sérgio Barcala Jorgept_BR
dc.creatorGislaine Cândida Batista Jorgept_BR
dc.creatorAlanna Fernandes Paraísopt_BR
dc.creatorRaissa Mendonça Porto Francopt_BR
dc.creatorLara Jhullian Tolentino Vieirapt_BR
dc.creatorAline Mourão Hilzendegerpt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorJoão Marcus Oliveira Andradept_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.date.accessioned2022-08-18T10:55:55Z-
dc.date.available2022-08-18T10:55:55Z-
dc.date.issued2017-
dc.citation.volume125pt_BR
dc.citation.issue3pt_BR
dc.citation.spage163pt_BR
dc.citation.epage170pt_BR
dc.identifier.doi10.1055/s-0042-119525pt_BR
dc.identifier.issn1439-3646pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44341-
dc.description.resumoAim: the present study aimed to analyze the expression of IL6, UCP1 and SIRT1 in adipose tissue (WAT and BAT) in association to clinical, metabolic and anthropometric parameters in obese humans. Methods: WAT and BAT samples from obese patients (n=27) were collected. IL6, UCP1 and SIRT1 markers were measured by qRT-PCR. The association between IL6, UCP1 and SIRT1 mRNA expression and anthropometric and clinical parameters were evaluated, using appropriate statistical tests. Results: our results demonstrated that high levels of IL6 are associated with altered glucose levels in the WAT (p=0.01). In contrast, high levels of IL6 in the BAT were associated with decreased % fat (p=0.01) and fat weight (p=0.02) and increased mVO2 (p=0.02) and VO2 (p=0.02). For UCP1, a higher expression in the BAT was observed when compared to the WAT (p=0.0001). This gene expression was associated with lower values of BMI (p=0.03), % fat (P=0.02) and fat weight (P=0.02) and increased mVO2 (p=0.041) and VO2 (p=0.001). In the WAT, decreased levels of SIRT1 were associated with increased fat weight (p=0.02); in the BAT, associations were found for % fat (p=0.018) and mVO2 (p=0.03). Conclusion: these results reveal different characteristics in the biological actions between WAT and BAT in obese humans. Increased levels of IL6, UCP1 and SIRT1 in the BAT were associated with metabolic parameters improvements.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofExperimental and Clinical Endocrinology & Diabetespt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherTecido adiposo marrompt_BR
dc.subject.otherInterleucina-2pt_BR
dc.subject.otherAntropometriapt_BR
dc.titleBrown and white adipose tissue expression of IL6, UCP1 and SIRT1 are associated with alterations in clinical, metabolic and anthropometric parameters in obese humanspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0042-119525pt_BR
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