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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44343
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dc.creatorSimone Moreira de Macêdopt_BR
dc.creatorDeborah de Farias Lelispt_BR
dc.creatorKeila Lopes Mendespt_BR
dc.creatorCarlos Alberto de Carvalho Fragapt_BR
dc.creatorIgor Viana Brandipt_BR
dc.creatorJohn David Feltenbergerpt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.date.accessioned2022-08-18T12:13:23Z-
dc.date.available2022-08-18T12:13:23Z-
dc.date.issued2017-05-01-
dc.citation.volume15pt_BR
dc.citation.issue4pt_BR
dc.citation.spage161pt_BR
dc.citation.epage169pt_BR
dc.identifier.doihttp://doi.org/10.1089/met.2016.0109pt_BR
dc.identifier.issn1557-8518pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44343-
dc.description.resumoBackground: fibronectin type III domain containing 5 (FNDC5) and its protein product Irisin are therapeutic targets for obesity-associated disorders. Irisin plays an important role in energy regulation, inducing browning of white adipocytes, and improving obesity. We aimed to investigate the association between muscle Irisin expression and dietary quality. Methods: twenty-eight female mice were divided into four groups and fed the following experimental diets for 60 days: standard diet (SD), high-carbohydrate diet (HCD), high-fat diet (HFD), and high-protein diet (HPD). We evaluated body weight, food intake, serum total cholesterol, triacylglycerol, and glucose. We also performed glucose tolerance and insulin sensitivity tests. Expression of FNDC5 was evaluated by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) of soleus muscle. Western blot was used to assess Irisin protein expression. Results: the major finding of the present study was that HFD and HCD were associated with a downregulation of FNDC5. In addition to these results, we noted a significant reduction in skeletal muscle Irisin level. HPD prevented reductions of both FNDC5 and Irisin levels, as well as increased brown adipose tissue, compared to the control group. Conclusions: in conclusion, we observed that the HPD type of diet can change both FNDC5 expression and Irisin levels. Thus, the HPD might be the most appropriate diet to achieve high amounts of Irisin, a target molecule for the treatment of obesity and its co-morbidities.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMetabolic Syndrome and Related Disorderspt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherFibronectinaspt_BR
dc.subject.otherDietapt_BR
dc.subject.otherMúsculos esqueléticospt_BR
dc.titleEffects of dietary macronutrient composition on FNDC5 and irisin in mice skeletal musclept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.liebertpub.com/doi/10.1089/met.2016.0109pt_BR
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