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Type:	Artigo de Periódico
Title:	Interleukin-1β (rs1143634) polymorphism and adiposity traits in Quilombolas
Authors:	Geórgia das Graças Pena Rosângela Ramos Veloso Silva Mayane Moura Pereira Tatiana Carvalho Reis Martins Lucyana Conceição Farias Emisael Stênio Batista Gomes João Felício Rodrigues Neto Alfredo Maurício Batista de Paula Sérgio Henrique Sousa Santos Antônio Prates Caldeira André Luiz Sena Guimarães
Abstract:	Background: recent studies have shown a relationship between adiposity traits and a low-grade inflammation of adipose tissue resulting from chronic activation of the innate immune system as interleukin-1 beta (IL-1β). However, this association remains controversial. Besides, the Quilombola communities that have presumed different genetic background and it could change the obesity vulnerability. Objective: to estimate the association between IL-1β and adiposity traits like obesity or abdominal obesity in Quilombola communities. A cross-sectional population-based study was conducted the northern region of Minas Gerais with the representative sample of 756 individuals aged ≥ 18 years. The swab oral was used for DNA extraction and the IL-1β rs1143634 polymorphism was evaluated by RFLP-PCR. The interviewed and measures were done using specific protocols. It was estimated to outcomes: the overweight (body mass index ≥ 25 kg/m2), abdominal obesity (waist circumference ≥ 88 cm for women and ≥ 102 cm for men), and the high conicity index (≥ 1.18 cm or women e ≥ 1.25 cm for men). Poisson regression multivariate models were constructed considering genotype and the outcomes, adjusted for socioeconomic and lifestyle variables. Results: the distribution of IL-1β for the TT genotype was (11.9%), CT (25.1%) and CC (63.0%). The women TT carriers showed a higher regular soft drink consumption (p = 0.048). The height was lower in man TT carriers (p = 0.041) and lower weight (p = 0.025). The CT genotype showed higher BMI (p = 0.037). The CT and TT carriers showed less prevalence ratio to abdominal obesity even adjusted to socioeconomic and lifestyle variables, there no associations between genotype and overweight or high conicity index. Conclusions: in conclusion, after socioeconomic and lifestyle adjustment T variant of rs1143634 is a protection factor for central obesity in Quilombola communities.
Subject:	Polimorfismo (Genética) Antropometria Interleucina-1beta Tecido adiposo Obesidade Quilombolas
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.mgene.2017.05.004
URI:	http://hdl.handle.net/1843/44378
Issue Date:	Sep-2017
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S2214540017300385
metadata.dc.relation.ispartof:	Meta Gene
Appears in Collections:	Artigo de Periódico

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