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http://hdl.handle.net/1843/44379| Type: | Artigo de Periódico |
| Title: | Effects of sleeve gastrectomy on the metabolic profile and on the expression of renin-angiotensin system in adipose tissue of obese rats |
| Authors: | Thaisa Soares Crespo João Marcus Oliveira Andrade Alanna Fernandes Paraíso Deborah de Farias Lelis Pablo Vinicyus Ferreira Chagas Antônio Sergio Barcala Jorge Wagner Leite Ferreira Alfredo Maurício Batista de Paula André Luiz Sena Guimarães Sergio Henrique Sousa Santos |
| Abstract: | Background: sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of obesity. Objectives: the present study aimed to assess the effects of SG on the metabolic and inflammatory profile and renin-angiotensin system (RAS) expression in the white adipose tissue of male rats with obesity induced by a high-fat diet. Methods: male Wistar rats were treated with a standard diet or high-fat diet and submitted to SG or sham surgery. The glycemic and lipid profiles and gene expression of inflammatory markers and RAS components in adipose tissue were evaluated. Results: SG led to weight loss, decreased adiposity (p < 0.01) and a reduction in plasma glucose (p < 0.05), C-peptide (p < 0.05), insulin (p < 0.001) and total cholesterol (p < 0.05) levels. In addition, SG led to a decrease in the expression of tumor necrosis factor-alpha (TNF-α) (p < 0.01), interleukin- 6 (IL-6) (p < 0.001), angiotensinogen (AGT) (p < 0.001) and angiotensin converting enzyme (ACE) (p < 0.05) and increased the expression of angiotensin converting enzyme 2 (ACE2) (p < 0.05) in white adipose tissue. No statistically significant differences were observed for AT1 (p = 0.10) and Mas (p = 0.22) receptors. Conclusion: this study showed that SG leads to weight loss and improves metabolic parameters. Changes in the expression of RAS components and of inflammatory molecules in adipose tissue seem to play a role the before beneficial effects of the SG. |
| Subject: | Gastrectomia Sistema renina-angiotensina Cirurgia bariátrica Obesidade Tecido adiposo |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.2174/0929866524666170728155926 |
| URI: | http://hdl.handle.net/1843/44379 |
| Issue Date: | 3-Mar-2017 |
| metadata.dc.url.externa: | http://www.eurekaselect.com/article/85070 |
| metadata.dc.relation.ispartof: | Protein and Peptide Letters |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Effects of Sleeve Gastrectomy on the Metabolic Profile and on the Expression of Renin-Angiotensin System in Adipose Tissue of Obese Rats.pdf | 5.79 MB | Adobe PDF | View/Open |
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