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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44433
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dc.creatorMarcela Gonçalves de Souzapt_BR
dc.creatorSabrina Ferreira de Jesuspt_BR
dc.creatorEloá Mangabeira Santospt_BR
dc.creatorEmisael Stênio Batista Gomespt_BR
dc.creatorArlen de Paulo Santiago Filhopt_BR
dc.creatorEliane Macedo Sobrinho Santospt_BR
dc.creatorLuiz Henrique da Silveirapt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.date.accessioned2022-08-22T13:24:41Z-
dc.date.available2022-08-22T13:24:41Z-
dc.date.issued2018-11-08-
dc.citation.volume26pt_BR
dc.citation.spage433pt_BR
dc.citation.epage442pt_BR
dc.identifier.doi10.1007/s12253-018-0517-2pt_BR
dc.identifier.issn1532-2807pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44433-
dc.description.resumoRadiation Therapy (RT) is a treatment option for a large number of neoplasias. However, the effect of RT on the level of hypoxia markers is poorly understood. The present study aimed to investigate the effect of RT on the levels of hypoxic markers in Oral squamous cell carcinoma (OSCC). Evaluation of HIF-1α and miR-210 levels in OSCC was performed. Then a proteomic analysis was performed to identify candidate hypoxic targets of RT. To validate proteomic studies, the effect of RT on HIF-1α, miR-210, PDH-A and LDH-A levels under hypoxia was assessed by qRT-PCR. The impact of RT in hypoxia markers was evaluated in patients to confirm in vitro results. An increase in the HIF-1α levels was observed in OSCC. RT reduced OSCC cell proliferation and migration. Interestingly, hypoxia could revert the effect of radiation on OSCC phenotype. However, proteomics analyses suggested that LDH is one of the critical targets of RT even in hypoxia. Moreover, RT decreased HIF-1α, miR-210, and LDH even in hypoxia. The current study demonstrated that hypoxia could revert the effects of RT in the OSCC context. However, RT reduces the levels HIF-1α, miR-210 and LDH in vivo and in vitro. The consequences of RT in blood should be carefully investigated.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPathology and Oncology Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherCâncer - Radioterapiapt_BR
dc.subject.otherLactato desidrogenasept_BR
dc.subject.otherCarcinoma de células escamosaspt_BR
dc.titleRadiation therapy reduced blood levels of LDH, HIF-1α, and miR-210 in OSCCpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s12253-018-0517-2pt_BR
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