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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/44449
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dc.creatorJamille Fernandes Lulapt_BR
dc.creatorToni Ramos Alves de Souzapt_BR
dc.creatorKeila Lopes Mendespt_BR
dc.creatorAlanna Fernandes Paraísopt_BR
dc.creatorDeborah de Farias Lelispt_BR
dc.creatorJoão Marcus Oliveira Andradept_BR
dc.creatorLucyana Conceição de Fariaspt_BR
dc.creatorIgor Viana Brandipt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAline Hilzenderguerpt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.date.accessioned2022-08-22T15:33:07Z-
dc.date.available2022-08-22T15:33:07Z-
dc.date.issued2018-
dc.citation.volume14pt_BR
dc.citation.issue3pt_BR
dc.citation.spage203pt_BR
dc.citation.epage209pt_BR
dc.identifier.doi10.2174/1573408014666180705145324pt_BR
dc.identifier.issn1875-6662pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/44449-
dc.description.resumoBackground: the renin-angiotensin system (RAS) is a critical contributing factor to obesity and related diseases. Several studies have shown the relationship of obesity with cyclooxygenase-2. Objectives: based on these facts, we aimed to investigate the celecoxib oral administration (a selective anti-inflammatory inhibitor of cyclooxygenase-2 (ICOX-2)) effects, in mice fed a high-fat diet by assessing the renin-angiotensin system and inflammatory markers expression. Methods: FVB/N male mice were divided into 3 groups and fed with experimental diets, standard, high-fat diet and high-fat diet plus ICOX-2 at a dose of 100mg/kg/body weight. Body weight, food intake, blood parameters and RAS/inflammatory markers expression were assessed. Results: the main findings showed that diet-induced obese mice treated with COX-2 inhibitor showed significantly improved glucose and insulin homeostasis, presented decreased body weight gain and the biochemical analyses revealed reduced triglyceride levels and higher serum HDL-c levels as compared to HFD and ST. These results were accompanied by a downregulation of AGT, ACE, TNF-α and IL-6 expression in the group receiving treatment. Conclusion: taken together, these results indicate that ICOX-2 may exhibit therapeutic potential for obesity via the renin-angiotensin system and inflammation.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCurrent Enzyme Inhibitionpt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherSistema renina-angiotensinapt_BR
dc.subject.otherAnalgésicospt_BR
dc.subject.otherAgentes antiinflamatórios não esteróidespt_BR
dc.titleCelecoxib modulates renin-angiotensin system in the adipose tissue of obese micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttp://www.eurekaselect.com/article/91529pt_BR
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